Special Issue "iPS Cells for Modelling and Treatment of Human Diseases"


A special issue of Journal of Clinical Medicine (ISSN 2077-0383).

Deadline for manuscript submissions: closed (31 July 2014)

Special Issue Editor

Guest Editor
Dr. Michael J. Edel
Departament de Ciències Fisiològiques I, Facultat de Medicina, Universitat de Barcelona, Spain
E-Mail: michaeledel@ub.edu
Phone: +34 93 402 4518
Interests: reprogramming to pluripotency; direct reprogramming; embryological development; cell cycle; cancer biology; 3D organ bioengineering; clinical grade cell replacement therapy

Special Issue Information

Dear Colleagues,

The field of reprogramming somatic cells into induced pluripotent stem cells (iPSC) has moved very quickly, from bench to bedside in just eight years since its first discovery. The best example of this is the RIKEN clinical trial this year in Japan, which will use iPSC derived retinal pigmented epithelial (RPE) cells to treat macular degeneration (MD). This is the first human disease to be tested for regeneration and repair by iPSC-derived cells and others will follow in the near future. Currently, there is an intense worldwide research effort to bring stem cell technology to the clinic for application to treat human diseases and pathologies. Human tissue diseases (including those of the lung, heart, brain, spinal cord, and muscles) drive organ bioengineering to the forefront of technology concerning cell replacement therapy. Given the critical mass of research and translational work being performed, iPSCs may very well be the cell type of choice for regenerative medicine in the future. Also, basic science questions, such as efficient differentiation protocols to the correct cell type for regenerating human tissues, the immune response of iPSC replacement therapy and genetic stability of iPSC-derived cells, are currently being investigated for future clinical applications. Please join us in presenting this Special Issue on the state of the art research currently being performed worldwide to bring iPSC to the clinic so as to help understand and treat various human diseases.

Dr. Michael J. Edel
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • induced pluripotent stem cells
  • differentiation
  • adult stem cell
  • human disease
  • clinical application
  • immune response
  • genetic cell stability

Published Papers (1 paper)

Display options:
Select articles Export citation of selected articles as:
Select/unselect all
Displaying article 1-1
p. 997-1017
by ,  and
J. Clin. Med. 2014, 3(3), 997-1017; doi:10.3390/jcm3030997
Received: 17 July 2014; in revised form: 22 August 2014 / Accepted: 26 August 2014 / Published: 5 September 2014
Show/Hide Abstract | PDF Full-text (752 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue iPS Cells for Modelling and Treatment of Human Diseases)
Select/unselect all
Displaying article 1-1
Select articles Export citation of selected articles as:

Last update: 3 April 2014

J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert