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J. Clin. Med. 2014, 3(4), 1357-1372; doi:10.3390/jcm3041357

Opportunities and Limitations of Modelling Alzheimer’s Disease with Induced Pluripotent Stem Cells

Stem Cell Engineering Group, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia 4072, Australia
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Received: 27 August 2014 / Revised: 31 October 2014 / Accepted: 12 November 2014 / Published: 5 December 2014
(This article belongs to the Special Issue iPS Cells for Modelling and Treatment of Human Diseases)
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Abstract

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) has opened the way for patient-specific disease modelling. Following their differentiation into neuronal cell types, iPSC have enabled the investigation of human neurodegenerative diseases, such as Alzheimer’s disease (AD). While human iPSCs certainly provide great opportunities to repeatedly interrogate specific human brain cell types of individuals with familial and sporadic forms of the disease, the complex aetiology and timescale over which AD develops in humans poses particular challenges to iPSC-based AD models. Here, we discuss the current state-of-play in the context of these and other iPSC model-related challenges and elaborate on likely future developments in this field of research. View Full-Text
Keywords: induced pluripotent stem cells; Alzheimer’s disease; disease modelling; reprogramming induced pluripotent stem cells; Alzheimer’s disease; disease modelling; reprogramming
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Ovchinnikov, D.A.; Wolvetang, E.J. Opportunities and Limitations of Modelling Alzheimer’s Disease with Induced Pluripotent Stem Cells. J. Clin. Med. 2014, 3, 1357-1372.

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