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J. Clin. Med. 2014, 3(4), 1064-1083; doi:10.3390/jcm3041064

Human iPS Cell-Derived Germ Cells: Current Status and Clinical Potential

Office of Health and Safety, Hokkaido University, Sapporo 060-0808, Japan
Received: 30 July 2014 / Revised: 17 September 2014 / Accepted: 22 September 2014 / Published: 13 October 2014
(This article belongs to the Special Issue iPS Cells for Modelling and Treatment of Human Diseases)
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Abstract

Recently, fertile spermatozoa and oocytes were generated from mouse induced pluripotent (iPS) cells using a combined in vitro and in vivo induction system. With regard to germ cell induction from human iPS cells, progress has been made particularly in the male germline, demonstrating in vitro generation of haploid, round spermatids. Although iPS-derived germ cells are expected to be developed to yield a form of assisted reproductive technology (ART) that can address unmet reproductive needs, genetic and/or epigenetic instabilities abound in iPS cell generation and germ cell induction. In addition, there is still room to improve the induction protocol in the female germline. However, rapid advances in stem cell research are likely to make such obstacles surmountable, potentially translating induced germ cells into the clinical setting in the immediate future. This review examines the current status of the induction of germ cells from human iPS cells and discusses the clinical potential, as well as future directions. View Full-Text
Keywords: induced pluripotent stem cells; germ cells; primordial germ cells; oocyte; sperm; gametogenesis; meiosis; assisted reproductive technology; in vitro fertilization; intracytoplasmic sperm injection induced pluripotent stem cells; germ cells; primordial germ cells; oocyte; sperm; gametogenesis; meiosis; assisted reproductive technology; in vitro fertilization; intracytoplasmic sperm injection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ishii, T. Human iPS Cell-Derived Germ Cells: Current Status and Clinical Potential. J. Clin. Med. 2014, 3, 1064-1083.

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