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J. Clin. Med. 2015, 4(2), 318-342; doi:10.3390/jcm4020318

Potential Role of Induced Pluripotent Stem Cells (IPSCs) for Cell-Based Therapy of the Ocular Surface

1
Department of Surgery, School of Medicine and Hospital Clínic de Barcelona (IDIBAPS), University of Barcelona, Calle Sabino de Arana 1 (2nd floor), E-08028 Barcelona, Spain
2
CellTec-UB and the Clinic Foundation for Biomedical Research (FCRB), University of Barcelona, Avda. Diagonal 643, E-08028 Barcelona, Spain
3
Tissue Bank of BST (GenCat), Calle Dr Antoni Pujadas 42, SSMM Sant Joan de Déu, Edifici Pujadas, E-08830 Sant Boi de Llobregat, Spain
4
Pluripotency Group, Department of Physiology I, School of Medicine, University of Barcelona, Calle Casanovas 143, E-08036 Barcelona, Spain
5
Faculty of Medicine, Children's Hospital, University of Sydney, 2006 NSW, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: David T. Harris
Received: 23 November 2014 / Revised: 24 December 2014 / Accepted: 4 January 2015 / Published: 12 February 2015
(This article belongs to the Special Issue iPS Cells for Modelling and Treatment of Human Diseases)
View Full-Text   |   Download PDF [248 KB, uploaded 12 February 2015]   |  

Abstract

The integrity and normal function of the corneal epithelium are crucial for maintaining the cornea’s transparency and vision. The existence of a cell population with progenitor characteristics in the limbus maintains a dynamic of constant epithelial repair and renewal. Currently, cell-based therapies for bio replacement—cultured limbal epithelial transplantation (CLET) and cultured oral mucosal epithelial transplantation (COMET)—present very encouraging clinical results for treating limbal stem cell deficiency (LSCD) and restoring vision. Another emerging therapeutic approach consists of obtaining and implementing human progenitor cells of different origins in association with tissue engineering methods. The development of cell-based therapies using stem cells, such as human adult mesenchymal or induced pluripotent stem cells (IPSCs), represent a significant breakthrough in the treatment of certain eye diseases, offering a more rational, less invasive, and better physiological treatment option in regenerative medicine for the ocular surface. This review will focus on the main concepts of cell-based therapies for the ocular surface and the future use of IPSCs to treat LSCD. View Full-Text
Keywords: limbal stem cells; cornea; limbal stem cell deficiency; epithelial differentiation; human adult progenitor cells; ex vivo expansion; cell culture; ocular burns; cell-based therapy; human stem cells limbal stem cells; cornea; limbal stem cell deficiency; epithelial differentiation; human adult progenitor cells; ex vivo expansion; cell culture; ocular burns; cell-based therapy; human stem cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Casaroli-Marano, R.P.; Nieto-Nicolau, N.; Martínez-Conesa, E.M.; Edel, M.; B.Álvarez-Palomo, A. Potential Role of Induced Pluripotent Stem Cells (IPSCs) for Cell-Based Therapy of the Ocular Surface. J. Clin. Med. 2015, 4, 318-342.

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