Special Issue "Advances in Molecular Recognition"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Recognition".

Deadline for manuscript submissions: closed (31 October 2010)

Special Issue Editor

Guest Editor
Prof. Dr. A. Keith Dunker
Department of Biochemistry and Molecular Biology, Indiana University Schools of Medicine & Informatics, 410 W. 10th Street, Suite 5000, Indianapolis, IN 46202, USA
Website: http://compbio.iupui.edu/people/details/8
E-Mail: kedunker@iupui.edu

Special Issue Information

Dear Colleagues,

Molecular recognition is the specific interaction of one molecule with another by means of noncovalent bonds and hydrophobic effects. Molecular recognition can lead to the formation of a stable or transient complex between the two molecules or can lead to more complex interactions that result in associated allostery, catalysis, or even assembly of molecular machines. The interacting molecular pair can vary widely in size and complexity, from small molecules or even metal ions, to large proteins, nucleic acids, lipid assemblies, and carbohydrates. Molecular recognition is the most fundamental process underpinning life. Virtually every cellular activity can be viewed as a spatially and temporally ordered series of molecular recognition steps involving two or more molecules at each step.

Over the years a variety of models have been proposed to explain molecular recognition from the most fundamental level to the highest level of complexity. These models include, for small molecules, stereochemical fit among others, and for biological molecules, the lock and key, induced fit, conformational selection and coupled binding and folding. Recently very detailed computational models are being explored that probe shape, hydrogen bonding, and charge complementarity. Given the recent advances in high level models and in experimental and computational techniques that identify and probe molecular recognition events, it is time for an update in this rapidly advancing area.

Prof. Dr. A. Keith Dunker
Guest Editor

Keywords

  • lock and key
  • induced fit
  • coupled binding and folding
  • conformational selection
  • multispecificity

Published Papers (20 papers)

by ,  and
Int. J. Mol. Sci. 2010, 11(4), 1808-1824; doi:10.3390/ijms11041808
Received: 1 March 2010; in revised form: 23 March 2010 / Accepted: 14 April 2010 / Published: 16 April 2010
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by ,  and
Int. J. Mol. Sci. 2010, 11(4), 1930-1943; doi:10.3390/ijms11041930
Received: 23 February 2010; in revised form: 17 March 2010 / Accepted: 18 April 2010 / Published: 26 April 2010
Show/Hide Abstract | Cited by 33 | PDF Full-text (1366 KB) | HTML Full-text | XML Full-textCorrection | Supplementary Files
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by  and
Int. J. Mol. Sci. 2010, 11(8), 3016-3034; doi:10.3390/ijms11083016
Received: 11 May 2010; in revised form: 30 July 2010 / Accepted: 4 August 2010 / Published: 18 August 2010
Show/Hide Abstract | Cited by 40 | PDF Full-text (180 KB) | HTML Full-text | XML Full-text
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by  and
Int. J. Mol. Sci. 2010, 11(9), 3177-3194; doi:10.3390/ijms11093177
Received: 11 August 2010; in revised form: 24 August 2010 / Accepted: 3 September 2010 / Published: 9 September 2010
Show/Hide Abstract | Cited by 3 | PDF Full-text (1799 KB) | HTML Full-text | XML Full-text

by  and
Int. J. Mol. Sci. 2010, 11(9), 3334-3348; doi:10.3390/ijms11093334
Received: 30 July 2010; in revised form: 19 August 2010 / Accepted: 12 September 2010 / Published: 15 September 2010
Show/Hide Abstract | Cited by 15 | PDF Full-text (516 KB) | HTML Full-text | XML Full-text

by  and
Int. J. Mol. Sci. 2010, 11(10), 3623-3648; doi:10.3390/ijms11103623
Received: 2 July 2010; in revised form: 29 July 2010 / Accepted: 16 September 2010 / Published: 28 September 2010
Show/Hide Abstract | Cited by 16 | PDF Full-text (1919 KB) | HTML Full-text | XML Full-text

by ,  and
Int. J. Mol. Sci. 2010, 11(10), 3725-3747; doi:10.3390/ijms11103725
Received: 3 September 2010; in revised form: 10 September 2010 / Accepted: 15 September 2010 / Published: 29 September 2010
Show/Hide Abstract | Cited by 8 | PDF Full-text (267 KB) | HTML Full-text | XML Full-text

by , , , ,  and
Int. J. Mol. Sci. 2010, 11(12), 4864-4881; doi:10.3390/ijms11124864
Received: 1 November 2010; in revised form: 18 November 2010 / Accepted: 18 November 2010 / Published: 26 November 2010
Show/Hide Abstract | Cited by 30 | PDF Full-text (416 KB) | HTML Full-text | XML Full-text
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by , , , ,  and
Int. J. Mol. Sci. 2010, 11(12), 4991-5008; doi:10.3390/ijms11124991
Received: 28 October 2010; in revised form: 17 November 2010 / Accepted: 30 November 2010 / Published: 3 December 2010
Show/Hide Abstract | Cited by 9 | PDF Full-text (458 KB) | HTML Full-text | XML Full-text | Supplementary Files
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by  and
Int. J. Mol. Sci. 2010, 11(12), 5009-5026; doi:10.3390/ijms11125009
Received: 2 November 2010; in revised form: 2 December 2010 / Accepted: 3 December 2010 / Published: 6 December 2010
Show/Hide Abstract | Cited by 10 | PDF Full-text (779 KB) | HTML Full-text | XML Full-text

by  and
Int. J. Mol. Sci. 2010, 11(12), 5129-5142; doi:10.3390/ijms11125129
Received: 8 October 2010; in revised form: 22 November 2010 / Accepted: 7 December 2010 / Published: 13 December 2010
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by ,  and
Int. J. Mol. Sci. 2010, 11(12), 5212-5233; doi:10.3390/ijms1112521
Received: 11 November 2010; in revised form: 9 December 2010 / Accepted: 9 December 2010 / Published: 17 December 2010
Show/Hide Abstract | Cited by 6 | PDF Full-text (423 KB) | HTML Full-text | XML Full-text

by ,  and
Int. J. Mol. Sci. 2010, 11(12), 5292-5309; doi:10.3390/ijms11125292
Received: 19 October 2010; in revised form: 17 December 2010 / Accepted: 17 December 2010 / Published: 21 December 2010
Show/Hide Abstract | Cited by 13 | PDF Full-text (203 KB) | HTML Full-text | XML Full-text
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by , ,  and
Int. J. Mol. Sci. 2011, 12(1), 226-251; doi:10.3390/ijms12010226
Received: 2 November 2010; in revised form: 22 December 2010 / Accepted: 4 January 2011 / Published: 5 January 2011
Show/Hide Abstract | Cited by 5 | PDF Full-text (771 KB) | HTML Full-text | XML Full-text | Supplementary Files
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by  and
Int. J. Mol. Sci. 2011, 12(1), 334-352; doi:10.3390/ijms12010334
Received: 4 November 2010; in revised form: 19 December 2010 / Accepted: 5 January 2011 / Published: 13 January 2011
Show/Hide Abstract | Cited by 17 | PDF Full-text (273 KB) | HTML Full-text | XML Full-text
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by ,  and
Int. J. Mol. Sci. 2011, 12(2), 1316-1333; doi:10.3390/ijms12021316
Received: 10 December 2010; in revised form: 7 January 2011 / Accepted: 8 February 2011 / Published: 22 February 2011
Show/Hide Abstract | Cited by 3 | PDF Full-text (1538 KB) | HTML Full-text | XML Full-text
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by  and
Int. J. Mol. Sci. 2011, 12(2), 1410-1430; doi:10.3390/ijms12021410
Received: 25 January 2011; in revised form: 10 February 2011 / Accepted: 16 February 2011 / Published: 23 February 2011
Show/Hide Abstract | Cited by 5 | PDF Full-text (1580 KB) | HTML Full-text | XML Full-text | Supplementary Files
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by  and
Int. J. Mol. Sci. 2011, 12(3), 1431-1450; doi:10.3390/ijms12031431
Received: 25 January 2011; in revised form: 10 February 2011 / Accepted: 17 February 2011 / Published: 24 February 2011
Show/Hide Abstract | Cited by 1 | PDF Full-text (2679 KB) | HTML Full-text | XML Full-text

by  and
Int. J. Mol. Sci. 2011, 12(3), 2019-2035; doi:10.3390/ijms12032019
Received: 10 January 2011; in revised form: 2 March 2011 / Accepted: 14 March 2011 / Published: 21 March 2011
Show/Hide Abstract | Cited by 3 | PDF Full-text (1328 KB) | HTML Full-text | XML Full-text

by , ,  and
Int. J. Mol. Sci. 2013, 14(2), 3228-3253; doi:10.3390/ijms14023228
Received: 27 December 2012; in revised form: 25 January 2013 / Accepted: 28 January 2013 / Published: 5 February 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (735 KB) | HTML Full-text | XML Full-text
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Last update: 26 February 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert