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Hub Promiscuity in Protein-Protein Interaction Networks
Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan
Graduate School of Information Sciences, Tohoku University, 6-3-09, Aramaki-aza-aoba, Aoba-ku, Miyagi, 982-0036, Japan
Bioinformatics Research and Development, Japan Science and Technology Corporation, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
* Author to whom correspondence should be addressed.
Received: 23 February 2010; in revised form: 17 March 2010 / Accepted: 18 April 2010 / Published: 26 April 2010
Abstract: Hubs are proteins with a large number of interactions in a protein-protein interaction network. They are the principal agents in the interaction network and affect its function and stability. Their specific recognition of many different protein partners is of great interest from the structural viewpoint. Over the last few years, the structural properties of hubs have been extensively studied. We review the currently known features that are particular to hubs, possibly affecting their binding ability. Specifically, we look at the levels of intrinsic disorder, surface charge and domain distribution in hubs, as compared to non-hubs, along with differences in their functional domains.
Keywords: protein-protein interactions; interaction networks; hubs; promiscuous binding
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MDPI and ACS Style
Patil, A.; Kinoshita, K.; Nakamura, H. Hub Promiscuity in Protein-Protein Interaction Networks. Int. J. Mol. Sci. 2010, 11, 1930-1943.
Patil A, Kinoshita K, Nakamura H. Hub Promiscuity in Protein-Protein Interaction Networks. International Journal of Molecular Sciences. 2010; 11(4):1930-1943.
Patil, Ashwini; Kinoshita, Kengo; Nakamura, Haruki. 2010. "Hub Promiscuity in Protein-Protein Interaction Networks." Int. J. Mol. Sci. 11, no. 4: 1930-1943.