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Hub Promiscuity in Protein-Protein Interaction Networks
AbstractHubs are proteins with a large number of interactions in a protein-protein interaction network. They are the principal agents in the interaction network and affect its function and stability. Their specific recognition of many different protein partners is of great interest from the structural viewpoint. Over the last few years, the structural properties of hubs have been extensively studied. We review the currently known features that are particular to hubs, possibly affecting their binding ability. Specifically, we look at the levels of intrinsic disorder, surface charge and domain distribution in hubs, as compared to non-hubs, along with differences in their functional domains.
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Patil, A.; Kinoshita, K.; Nakamura, H. Hub Promiscuity in Protein-Protein Interaction Networks. Int. J. Mol. Sci. 2010, 11, 1930-1943.View more citation formats
Patil A, Kinoshita K, Nakamura H. Hub Promiscuity in Protein-Protein Interaction Networks. International Journal of Molecular Sciences. 2010; 11(4):1930-1943.Chicago/Turabian Style
Patil, Ashwini; Kinoshita, Kengo; Nakamura, Haruki. 2010. "Hub Promiscuity in Protein-Protein Interaction Networks." Int. J. Mol. Sci. 11, no. 4: 1930-1943.