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A correction was published on 27 July 2010, see Int. J. Mol. Sci. 2010, 11(8), 2791.

Int. J. Mol. Sci. 2010, 11(4), 1930-1943; doi:10.3390/ijms11041930
Review

Hub Promiscuity in Protein-Protein Interaction Networks

1
, 2,3
 and 4,*
1 Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan 2 Graduate School of Information Sciences, Tohoku University, 6-3-09, Aramaki-aza-aoba, Aoba-ku, Miyagi, 982-0036, Japan 3 Bioinformatics Research and Development, Japan Science and Technology Corporation, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan 4 Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
* Author to whom correspondence should be addressed.
Received: 23 February 2010 / Revised: 17 March 2010 / Accepted: 18 April 2010 / Published: 26 April 2010
(This article belongs to the Special Issue Advances in Molecular Recognition)
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Abstract

Hubs are proteins with a large number of interactions in a protein-protein interaction network. They are the principal agents in the interaction network and affect its function and stability. Their specific recognition of many different protein partners is of great interest from the structural viewpoint. Over the last few years, the structural properties of hubs have been extensively studied. We review the currently known features that are particular to hubs, possibly affecting their binding ability. Specifically, we look at the levels of intrinsic disorder, surface charge and domain distribution in hubs, as compared to non-hubs, along with differences in their functional domains.
Keywords: protein-protein interactions; interaction networks; hubs; promiscuous binding protein-protein interactions; interaction networks; hubs; promiscuous binding
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Patil, A.; Kinoshita, K.; Nakamura, H. Hub Promiscuity in Protein-Protein Interaction Networks. Int. J. Mol. Sci. 2010, 11, 1930-1943.

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