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A correction was published on 27 July 2010, see Int. J. Mol. Sci. 2010, 11(8), 2791.

Int. J. Mol. Sci. 2010, 11(4), 1930-1943; doi:10.3390/ijms11041930

Hub Promiscuity in Protein-Protein Interaction Networks

, 2,3
 and 4,*
Received: 23 February 2010 / Revised: 17 March 2010 / Accepted: 18 April 2010 / Published: 26 April 2010
(This article belongs to the Special Issue Advances in Molecular Recognition)
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Abstract: Hubs are proteins with a large number of interactions in a protein-protein interaction network. They are the principal agents in the interaction network and affect its function and stability. Their specific recognition of many different protein partners is of great interest from the structural viewpoint. Over the last few years, the structural properties of hubs have been extensively studied. We review the currently known features that are particular to hubs, possibly affecting their binding ability. Specifically, we look at the levels of intrinsic disorder, surface charge and domain distribution in hubs, as compared to non-hubs, along with differences in their functional domains.
Keywords: protein-protein interactions; interaction networks; hubs; promiscuous binding protein-protein interactions; interaction networks; hubs; promiscuous binding
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Patil, A.; Kinoshita, K.; Nakamura, H. Hub Promiscuity in Protein-Protein Interaction Networks. Int. J. Mol. Sci. 2010, 11, 1930-1943.

AMA Style

Patil A, Kinoshita K, Nakamura H. Hub Promiscuity in Protein-Protein Interaction Networks. International Journal of Molecular Sciences. 2010; 11(4):1930-1943.

Chicago/Turabian Style

Patil, Ashwini; Kinoshita, Kengo; Nakamura, Haruki. 2010. "Hub Promiscuity in Protein-Protein Interaction Networks." Int. J. Mol. Sci. 11, no. 4: 1930-1943.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert