Special Issue "The Identification of the Genetic Components of Autism Spectrum Disorders 2017"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2017)
A printed edition of this Special Issue is available here.
Prof. Dr. Merlin G. Butler
Psychiatry and Behavioral Sciences, the University of Kansas Medical Center, 3901 Rainbow Blvd., Mail Stop 4015, Kansas City, KS 66160, USA
Website | E-Mail
Interests: genetics of autism; Prader-Willi syndrome; microarray analysis; CNVs; exome sequencing; genetics of obesity; delineation of rare diseases; genotype-phenotype correlations; intellectual disabilities; 15q11-q13 chromosome rearrangements
This journal issue is dedicated to the study of the genetics of autism and a collection of original research or review articles and studies related to this topic. Highlights in the field of autism research and identification and characterization of genetic components will be addressed. Autism spectrum disorders (ASD) are neurobehavioral disorders characterized by three behavioral domains and currently affect about 1% of children, however, this is on the rise. Significant genetic contributions and mechanisms underlie the causation of ASD. About 50% of individuals are diagnosed with chromosomal abnormalities, submicroscopic deletions or duplications, single gene disorders or metabolic disturbances. The advancement of genetic technology with high resolution structural and microarrays and bioinformatics has led to the discovery of well over 600 genes contributing to ASD. Further, next generation (exome) sequencing for ASD leading to potential pharmaceutical intervention/treatment may vary from patient to patient depending on the specific genomic finding and associated characteristics for autism. New discoveries and continued identification of candidate genes will be addressed and genotype-phenotype correlations. Genetic evaluations requiring the use of advanced genetic testing options will be discussed along with psychiatric/behavioral co-morbidities seen in ASD and approaches to treatment.
Prof. Dr. Merlin G. Butler
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- next generation (exome) sequencing
- copy number variants (CNVs) candidate genes
- autism and autism spectrum disorders (ASD)
- gene polymorphisms
- genetic causation
- gene expression
- non-coding RNAs