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Int. J. Mol. Sci. 2017, 18(4), 828; doi:10.3390/ijms18040828

Delineating the Common Biological Pathways Perturbed by ASD’s Genetic Etiology: Lessons from Network-Based Studies

Molecular and Behavioral Neurosciences Lab, Bar-Ilan University, Faculty of Medicine, 13215 Safed, Israel
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Author to whom correspondence should be addressed.
Academic Editor: Merlin G. Butler
Received: 28 February 2017 / Revised: 3 April 2017 / Accepted: 6 April 2017 / Published: 14 April 2017
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Abstract

In recent decades it has become clear that Autism Spectrum Disorder (ASD) possesses a diverse and heterogeneous genetic etiology. Aberrations in hundreds of genes have been associated with ASD so far, which include both rare and common variations. While one may expect that these genes converge on specific common molecular pathways, which drive the development of the core ASD characteristics, the task of elucidating these common molecular pathways has been proven to be challenging. Several studies have combined genetic analysis with bioinformatical techniques to uncover molecular mechanisms that are specifically targeted by autism-associated genetic aberrations. Recently, several analysis have suggested that particular signaling mechanisms, including the Wnt and Ca2+/Calmodulin-signaling pathways are often targeted by autism-associated mutations. In this review, we discuss several studies that determine specific molecular pathways affected by autism-associated mutations, and then discuss more in-depth into the biological roles of a few of these pathways, and how they may be involved in the development of ASD. Considering that these pathways may be targeted by specific pharmacological intervention, they may prove to be important therapeutic targets for the treatment of ASD. View Full-Text
Keywords: ASD; autism; networks; genetics; Fragile-X Syndrome; Wnt; mTOR; Calmodulin; Calcium; NGF ASD; autism; networks; genetics; Fragile-X Syndrome; Wnt; mTOR; Calmodulin; Calcium; NGF
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Oron, O.; Elliott, E. Delineating the Common Biological Pathways Perturbed by ASD’s Genetic Etiology: Lessons from Network-Based Studies. Int. J. Mol. Sci. 2017, 18, 828.

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