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Special Issue "The Beneficial Effects of Plant Oil on Human Health"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 October 2017

Special Issue Editor

Guest Editor
Dr. Gérard Lizard

Universite de Bourgogne Franche-Comté / Inserm, Dijon, France
Website | E-Mail

Special Issue Information

Dear Colleagues,

The use of several oils such as argan and olive oils for human health has attracted a great deal of interest. Argan oil has been used in traditional medicine, mainly in Morocco, as a natural remedy for several centuries. Olive oil is a major component of the mediterranean diet, and its benefits on the prevention on numerous diseases is well admitted. The rich composition of these oils in tocopherols, phytosterols, and unsaturated fatty acid makes them very interesting oils with respect to their actions on the risk factors of numerous diseases, mainly cardiovascular diseases, associated with hyperlipidemia, hypercholesterolemia, and hypertension. Argan oil is also traditionally used for the treatment of skin infections and in cosmetics. Beside these two important oils associated with the mediterranean diet, some other oils deriving from different plants are of interest to prevent or treat major human diseases. The objective of this Special Issue is to present different types of papers (research papers and reviews) gathering different topics, in order to provide a wide overview on the beneficial effects of plant oils on human health. The different topics include: oil production, oil composition, cosmetic, aged related diseases (cancer, metabolic diseases, cardiovascular diseases, neurodegenerative diseases, eye diseases, etc.), and nutrition. The cytoprotective effects of the major oil compounds on oxidation, inflammation, and cell death will be also considered.

Dr Gérard Lizard
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

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Open AccessArticle Protective Effect of Argan and Olive Oils against LPS-Induced Oxidative Stress and Inflammation in Mice Livers
Int. J. Mol. Sci. 2017, 18(10), 2181; doi:10.3390/ijms18102181 (registering DOI)
Received: 19 September 2017 / Revised: 10 October 2017 / Accepted: 12 October 2017 / Published: 19 October 2017
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Abstract
Sepsis causes severe dysregulation of organ functions, via the development of oxidative stress and inflammation. These pathophysiological mechanisms are mimicked in mice injected with bacterial lipopolysaccharide (LPS). Here, protective properties of argan oil against LPS-induced oxidative stress and inflammation are explored in the
[...] Read more.
Sepsis causes severe dysregulation of organ functions, via the development of oxidative stress and inflammation. These pathophysiological mechanisms are mimicked in mice injected with bacterial lipopolysaccharide (LPS). Here, protective properties of argan oil against LPS-induced oxidative stress and inflammation are explored in the murine model. Mice received standard chow, supplemented with argan oil (AO) or olive oil (OO) for 25 days, before septic shock was provoked with a single intraperitoneal injection of LPS, 16 hours prior to animal sacrifice. In addition to a rise in oxidative stress and inflammatory markers, injected LPS also caused hepatotoxicity, accompanied by hyperglycemia, hypercholesterolemia and hyperuremia. These LPS-associated toxic effects were blunted by AO pretreatment, as corroborated by normal plasma parameters and cell stress markers (glutathione: GSH) and antioxidant enzymology (catalase, CAT; superoxide dismutase, SOD and glutathione peroxidase, GPx). Hematoxylin–eosin staining revealed that AO can protect against acute liver injury, maintaining a normal status, which is pointed out by absent or reduced LPS-induced hepatic damage markers (i.e., alanine aminotransferase (ALT) and aspartate transaminase (AST)). Our work also indicated that AO displayed anti-inflammatory activity, due to down-regulations of genes encoding pro-inflammatory cytokines Interleukin-6 (IL-6) and Tumor Necrosis Factor-α (TNF-α) and in up-regulations of the expression of anti-inflammatory genes encoding Interleukin-4 (IL-4) and Interleukin-10 (IL-10). OO provided animals with similar, though less extensive, protective changes. Collectively our work adds compelling evidence to the protective mechanisms of AO against LPS-induced liver injury and hence therapeutic potentialities, in regard to the management of human sepsis. Activations of IL-4/Peroxisome Proliferator-Activated Receptors (IL-4/PPARs) signaling and, under LPS, an anti-inflammatory IL-10/Liver X Receptor (IL-10/LXR) route, obviously indicated the high potency and plasticity of the anti-inflammatory properties of argan oil. Full article
(This article belongs to the Special Issue The Beneficial Effects of Plant Oil on Human Health)
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Open AccessArticle Influence of a Virgin Olive Oil versus Butter Plus Cholesterol-Enriched Diet on Testicular Enzymatic Activities in Adult Male Rats
Int. J. Mol. Sci. 2017, 18(8), 1701; doi:10.3390/ijms18081701
Received: 19 June 2017 / Revised: 24 July 2017 / Accepted: 31 July 2017 / Published: 4 August 2017
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Abstract
The aim of the present work was to improve our knowledge on the mechanisms underlying the beneficial or deleterious effects on testicular function of the so-called Mediterranean and Western diet by analyzing glutamyl aminopeptidase (GluAP), gamma glutamyl transpeptidase (GGT) and dipeptidyl peptidase IV
[...] Read more.
The aim of the present work was to improve our knowledge on the mechanisms underlying the beneficial or deleterious effects on testicular function of the so-called Mediterranean and Western diet by analyzing glutamyl aminopeptidase (GluAP), gamma glutamyl transpeptidase (GGT) and dipeptidyl peptidase IV (DPP IV) activities in testis, as enzymes involved in testicular function. Male Wistar rats (6 months old) were fed for 24 weeks with three different diets: standard (S), an S diet supplemented with virgin-olive-oil (20%) (VOO), or a S diet enriched with butter (20%) plus cholesterol (0.1%) (Bch). At the end of the experimental period, plasma lipid profiled (total triglycerides, total cholesterol and cholesterol fractions (HDL, LDL and VDL)) were measured. Enzymatic activities were determined by fluorimetric methods in soluble (sol) and membrane-bound (mb) fractions of testicular tissue using arylamide derivatives as substrates. Results indicated an increase in plasmatic triglycerides, total cholesterol, LDL and VLDL in Bch. A significant increase of mb GluAP and GGT activities was also found in this diet in comparison with the other two diets. Furthermore, significant and positive correlations were established between these activities and plasma triglycerides and/or total cholesterol. These results support a role for testicular GluAP and GGT activities in the effects of saturated fat (Western diet) on testicular functions. In contrast, VOO increased sol DPP IV activity in comparison with the other two diets, which support a role for this activity in the effects of monounsaturated fat (Mediterranean diet) on testicular function. The present results strongly support the influence of fatty acids and cholesterol on testicular GluAP and GGT activities and also provide support that the reported beneficial influence of the Mediterranean diet in male fertility may be mediated in part by an increase of testicular sol DPP IV activity. Full article
(This article belongs to the Special Issue The Beneficial Effects of Plant Oil on Human Health)
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Other

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Open AccessMeeting Report Benefits of Argan Oil on Human Health—May 4–6 2017, Errachidia, Morocco
Int. J. Mol. Sci. 2017, 18(7), 1383; doi:10.3390/ijms18071383
Received: 8 June 2017 / Revised: 21 June 2017 / Accepted: 21 June 2017 / Published: 28 June 2017
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(This article belongs to the Special Issue The Beneficial Effects of Plant Oil on Human Health)
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