Special Issue "Nucleic Acid Probes"
A special issue of Chemosensors (ISSN 2227-9040).
Deadline for manuscript submissions: closed (31 August 2014)
Dr. Patrick J. Hrdlicka
Department of Chemistry, University of Idaho, 875 Perimeter Drive MS 2343, Moscow, ID-83844, USA
Phone: +1 208 885 0108
Interests: DNA recognition; DNA diagnostics; in vivo imaging; FISH; SNP detection; antisense; oligonucleotides; LNA; pyrene and intercalators
Revolutionary advances in genome sequencing and nucleic acid biology over the past 15 years have resulted in an explosion of data and knowledge about the identity, function and regulation of cellular DNA and RNA. This insight is increasingly harnessed for applications in molecular biology, biotechnology, and medicine. In parallel with these advances, there has been a growing need for techniques that enable detection of nucleic acids. Cleverly designed probes and assays are already used to localize RNA expression in living cells, perform advanced karyotyping, detect disease-related single nucleotide polymorphisms (SNPs), monitor enzyme activity, detect biological threat agents, and monitor PCR in real-time, to name only but a few important examples.
In this special issue of Chemosensors, we welcome communications, full papers and focused reviews on topics that pertain to the use of reporter-modified oligonucleotides and analogues thereof for the detection of nucleic acids and other biomolecules. This includes - but is not limited to - development and characterization of novel reporter-modified oligonucleotides/PNA/polyamides, aptasensors, assays and biosensors. Emphasis should be on chemistry/technology development and proof-of-concept studies, rather than adaptation of a well-established probes/assays/sensors to a new biological target. Please join us in collecting some of the best work in this exciting area from laboratories worldwide.
Dr. Patrick J. Hrdlicka
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- DNA/RNA/triplex/quadruplex/i-DNA/Z-DNA/H-DNA detection
- detection via fluorescence, electrochemistry or EPR spectroscopy
- hybridization probes
- SNP-discriminating probes
- base-discriminating fluorescent nucleotides
- intrinsically fluorescent probes
- detection of abasic sites or insertion/deletion mutations
- elucidation of protein function
- molecular beacons
- dual probes
- FRET wires
- fluorescence in situ hybridization
- tricomponent reactions
- QUAL; ECHO; LNA; PNA; polyamides; TALEN; CRISPR
- zinc fingers
- gold nanoparticles