Special Issue "Receptor Tyrosine Kinases"


A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (15 November 2013)

Special Issue Editor

Guest Editor
Dr. Sassan Hafizi
School of Pharmacy and Biomedical Sciences, Division of Pharmacology, University of Portsmouth, UK
Website: http://www.port.ac.uk/departments/academic/pharmacy/staff/title,100046,en.html
E-Mail: sassan.hafizi@port.ac.uk
Interests: epigenetics; focal adhesion proteins; receptor tyrosine kinases; cell signalling; vitamin K; cancer; myelin; multiple sclerosis; brain tumours; renal carcinoma; cytoskeleton; cell migration

Special Issue Information

Dear Colleagues,

Since the earliest discoveries of growth factors in the 1950s and of transmembrane receptors for these factors that possess protein tyrosine kinase activity in the 1970s, the body of knowledge on receptor tyrosine kinases (RTKs) has increased appreciably. The uniqueness in structure and ligand-binding specificities of the ectodomain of RTKs determines their subclassification, and today we know of the existence of around 20 different RTK classes, with a number and diversity of ligands that is ever increasing. Despite this diversity, RTKs continue to together represent a major group of molecules that play important roles in both health and disease. Normal RTK function is associated with development, cell and tissue growth and differentiation and cell-cell and cell-matrix interaction, whereas RTK overactivity and/or overexpression is a common feature in many cancers. However, novel aspects to RTK structure and function are increasingly becoming apparent as more research is being done. Amongst these include ligand-dependent and -independent mechanisms of activation, alternative and unexpected receptor clustering patterns, spatial and temporal control of RTK signalling, intracellular RTK functions, RTKs as entry gateways for pathogens, and as highly attractive candidates in target-specific cancer therapy. The aim with this Special Issue of Cells is to offer an Open Access collection of scholarly reviews on the forefront of research on RTKs that covers all of the above aspects and more. We hope to provide a stimulating resource that will inform the student and the academic on the breadth and diversity of RTK biology. This is a field that is sure to maintain a high level of interest and research activity from both academic and industrial sectors with interests in science and medicine well into the future.

Dr. Sassan Hafizi
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • receptor tyrosine kinases
  • growth factor
  • signal transduction
  • phosphorylation
  • spatial and temporal signalling
  • tyrosine kinase domain
  • transmembrane domain
  • RTK class
  • dimerisation
  • docking protein
  • development
  • differentiation
  • cancer
  • monoclonal antibodies
  • small molecule inhibitors
  • anti-cancer drug resistance

Published Papers (5 papers)

Cells 2014, 3(2), 199-235; doi:10.3390/cells3020199
Received: 18 December 2013; in revised form: 12 March 2014 / Accepted: 21 March 2014 / Published: 4 April 2014
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Cells 2014, 3(1), 129-149; doi:10.3390/cells3010129
Received: 11 December 2013; in revised form: 11 February 2014 / Accepted: 12 February 2014 / Published: 19 February 2014
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Cells 2014, 3(1), 92-111; doi:10.3390/cells3010092
Received: 22 November 2013; in revised form: 7 February 2014 / Accepted: 7 February 2014 / Published: 14 February 2014
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Cells 2014, 3(1), 53-78; doi:10.3390/cells3010053
Received: 25 November 2013; in revised form: 14 January 2014 / Accepted: 20 January 2014 / Published: 27 January 2014
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Cells 2013, 2(4), 751-767; doi:10.3390/cells2040751
Received: 29 October 2013; in revised form: 19 November 2013 / Accepted: 27 November 2013 / Published: 6 December 2013
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Review
Title: Monomers, Dimers or Tetramers: Mechanisms of Activation of Receptor Tyrosine Kinases
Author: Ichiro N. Maruyama
Affiliation: Information Processing Biology Unit, Okinawa Institute of Science and Technology, Graduate University, 1919-1 Tancha, Onna-son, Kunigami, Okinawa 904-0495, Japan; E-Mail: ichi@oist.jp
Abstract: Receptor tyrosine kinases (RTKs) play essential roles in cellular processes including metabolism, cell-cycle control, survival, proliferation, motility and differentiation. All RTKs are single-pass transmembrane proteins, and bind polypeptide ligands, mainly growth factors. Recent progress has been made towards an understanding of molecular mechanisms by which RTKs are activated by ligand binding. In this review, we discuss mainly about the mechanism of activation by which the epidermal growth factor (EGF/ErbB) receptor family, based upon recent structural and functional studies, and also discuss about other RTKs such as receptors for insulin and nerve growth factor.

Last update: 19 February 2014

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