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How Do Gangliosides Regulate RTKs Signaling?
Structural and Functional Glycobiology Unit, UMR CNRS 8576, University of Sciences and Technologies of Lille, 59655 Villeneuve d'Ascq, France
INSERM U908, University of Sciences and Technologies of Lille, 59655 Villeneuve d'Ascq, France
* Author to whom correspondence should be addressed.
Received: 29 October 2013; in revised form: 19 November 2013 / Accepted: 27 November 2013 / Published: 6 December 2013
Abstract: Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains, where they interact with molecules of signal transduction pathways including receptors tyrosine kinases (RTKs). The role of gangliosides in the regulation of signal transduction has been reported in many cases and in a large number of cell types. In this review, we summarize the current knowledge on the biosynthesis of gangliosides and the mechanism by which they regulate RTKs signaling.
Keywords: receptor tyrosine kinase; gangliosides; glycosylation; cell signaling; glycolpid-enriched microdomains
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MDPI and ACS Style
Julien, S.; Bobowski, M.; Steenackers, A.; Le Bourhis, X.; Delannoy, P. How Do Gangliosides Regulate RTKs Signaling? Cells 2013, 2, 751-767.
Julien S, Bobowski M, Steenackers A, Le Bourhis X, Delannoy P. How Do Gangliosides Regulate RTKs Signaling? Cells. 2013; 2(4):751-767.
Julien, Sylvain; Bobowski, Marie; Steenackers, Agata; Le Bourhis, Xuefen; Delannoy, Philippe. 2013. "How Do Gangliosides Regulate RTKs Signaling?" Cells 2, no. 4: 751-767.