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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment

edited by

Tomasz Brzozowski

submission deadline 18 Aug 2026 | 2 articles | Viewed by 7028

Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’s disease

Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth

edited by Khondoker M. Akram

submission deadline 20 Aug 2026 | 3 articles | Viewed by 14389 | Submission Open

Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth

(This special issue belongs to the Section Cellular Pathology)

Ageing and Neurodegenerative Diseases, Second Edition

edited by Feng Wang and

Antonella Caccamo

submission deadline 20 Aug 2026 | 4 articles | Viewed by 14188 | Submission Open

Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling

(This special issue belongs to the Section Cellular Pathology)

Role of Gene Regulation in Neurological Disorders

edited by

Yujing Li

and Yulin Jin

submission deadline 20 Aug 2026 | 3 articles | Viewed by 5759 | Submission Open

Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)

(This special issue belongs to the Section Cell and Gene Therapy)

Advances in Molecular Research on Cancer Drug Targets and Drug Resistance

edited by

Yuhao Xie

Concettina La Motta

and Rakesh Kumar Srivastava

submission deadline 20 Aug 2026 | 3 articles | Viewed by 5308 | Submission Open

Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers

Pathophysiology of Signal Transduction in Cardiovascular and Pulmonary Disease: 2nd Edition

edited by

Yung-Hsin Yeh

and

Ying-Ju Lai

submission deadline 20 Aug 2026 | 1 articles | Viewed by 4433 | Submission Open

Keywords: cardiac arrhythmia; atrium; ventricle; pulmonary; vascular; signal transduction

(This special issue belongs to the Section Cellular Pathology)

Small-Molecule Approaches to Counteract Demyelination and Neurodegeneration

edited by David Lutz

submission deadline 20 Aug 2026 | 3 articles | Viewed by 3760 | Submission Open

Keywords: demyelination; neurorepair; small-molecule therapeutics; neurodegeneration

(This special issue belongs to the Section Cellular Neuroscience)

Mesenchymal Stem Cells in Cell Therapy, Regenerative Medicine, and Tissue Engineering

edited by

Marta Kot

and

Joni H. Ylostalo

submission deadline 20 Aug 2026 | 3 articles | Viewed by 1973 | Submission Open

Keywords: mesenchymal stem cells (MSCs); tissue engineering and scaffolds; regenerative medicine; cell-based therapies; differentiation and immunomodulation

(This special issue belongs to the Section Stem Cells)

Function of Stress Granules in Normal Cells and in Alzheimer’s Disease

edited by

Paul D. Coleman

and Benjamin Wolozin

submission deadline 20 Aug 2026 | 1 articles | Viewed by 958 | Submission Open

Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

Cellular and Molecular Insights into Age-Related Macular Degeneration

edited by

Neetu Kushwah

and

Raphaël Roduit

submission deadline 20 Aug 2026 | Viewed by 251 | Submission Open

Keywords: age-related macular degeneration (AMD); lipid metabolism/lipid dysregulation; retinal pigment epithelium (RPE); photoreceptors; complement system/complement dysregulation; neurodegeneration; retinal degeneration

(This special issue belongs to the Section Cellular Aging)

Metabolic, Signaling, and Transcriptomic Regulation of NK Cell Development and Functions

edited by

Subramaniam Malarkannan

submission deadline 20 Aug 2026 | Viewed by 249 | Submission Open

Keywords: NK cells; immunometabolism; mTOR; AMPK; JAK–STAT; checkpoint signaling; transcription factors; enhancers; epigenetics; chromatin accessibility; single-cell multi-omics; spatial transcriptomics; tumor microenvironment; immunotherapy; transplantation

(This special issue belongs to the Section Cellular Immunology)

Molecular Mechanisms of Trophoblast Differentiation

edited by Milica Jovanović Krivokuća and

Jianjun Wei

submission deadline 25 Aug 2026 | 2 articles | Viewed by 2196 | Submission Open

Keywords: trophoblast differentiation; cytotrophoblast; syncytiotrophoblast; extravillous trophoblast; trophoblast stem cells; molecular mechanisms; signaling pathways; epigenetic regulation

Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms

edited by Masmoudi-Kouki Olfa and

Gérard Lizard

submission deadline 25 Aug 2026 | 1 articles | Viewed by 1393 | Submission Open

Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling

(This special issue belongs to the Section Stem Cells)

Role of Oxidative Stress in Cardiovascular Diseases

edited by

Nevena Jeremic

and

Vladimir Jakovljevic

submission deadline 25 Aug 2026 | Viewed by 560 | Submission Open

Keywords: oxidative stress; reactive oxygen species (ROS); endothelial dysfunction; inflammation; cardiovascular pathology

(This special issue belongs to the Section Cells of the Cardiovascular System)

New Trends and Advances in Induced Neural Cells and iPSC Technologies

edited by

Guoqiang Sun

submission deadline 28 Aug 2026 | 1 articles | Viewed by 2882 | Submission Open

Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling

(This special issue belongs to the Section Cellular Neuroscience)

Signal Transduction and Targeted Therapy for Tumors

edited by

Rodolfo Daniel Cervantes-Villagrana

submission deadline 30 Aug 2026 | 6 articles | Viewed by 14368 | Submission Open

Keywords: cancer progression; metastasis; invasion; cancer signaling; cell communication; cancer neuroscience; tumor angiogenesis; target therapy; immunotherapy; drug resistance; anti-tumor therapy

(This special issue belongs to the Section Cell Signaling)

Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies

edited by

Qiwei Wang

submission deadline 30 Aug 2026 | 5 articles | Viewed by 10802 | Submission Open

Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies

(This special issue belongs to the Section Cellular Immunology)

Ocular Surface and Adnexal Diseases: Molecular Mechanisms and Treatment Progresses

edited by

Edit Tóth-Molnár

submission deadline 30 Aug 2026 | 5 articles | Viewed by 5404 | Submission Open

Keywords: ocular surface and adnexal diseases; dry eye disease; eyelid diseases; lacrimal gland diseases; molecular mechanisms; therapeutic strategies

The Lipid Metabolism and Signaling in Dry Eye Disease

edited by Ni Made Airanthi Kusuma Widjaja-Adhi and Marcin Golczak

submission deadline 30 Aug 2026 | Viewed by 492 | Submission Open

Keywords: lipid metabolism; meibogenesis; dry eye disease (DED); meibomian gland dysfunction (MGD); ocular surface; neuroinflammation; tear film; lipidomics; spatial transcriptomics; therapeutics development; molecular mechanisms

Epigenetic Plasticity: How Chromatin Dynamics Orchestrate Fundamental Life Processes

edited by

Roshan L. Shrestha

and Subhash Chandra Sethi

submission deadline 30 Aug 2026 | Viewed by 337 | Submission Open

Keywords: chromatin organization; chromatin remodelers; epigenetic modifications; epigenetic modifiers; chromosome segregation; transcription; DNA replication; DNA damage and repair; cancer; aging

(This special issue belongs to the Section Cell and Gene Therapy)

Molecular and Cellular Mechanisms and Novel Therapies of Ocular Disease

edited by Valery I. Shestopalov

submission deadline 30 Aug 2026 | Viewed by 261 | Submission Open

Keywords: ocular disease; neuroprotection; regeneration

(This special issue belongs to the Section Cellular Pathology)

New Advances in Targeted Therapy for Solid Tumor

edited by Jung Eun Park

submission deadline 30 Aug 2026 | Viewed by 243 | Submission Open

Keywords: CAR-X cells; antibody–drug conjugates (ADCs); bispecific/multi-specific antibodies; PROTACs; tumor microenvironment (TME); immune checkpoint blockade; metabolic reprogramming; patient-derived organoids (PDOs); 3D bioprinting

(This special issue belongs to the Section Cellular Pathology)

The Role of Cilia in Health and Diseases—2nd Edition

edited by Rim Hjeij

submission deadline 31 Aug 2026 | 6 articles | Viewed by 17093 | Submission Open

Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy

Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy

edited by

Javier S. Castresana

submission deadline 31 Aug 2026 | 6 articles | Viewed by 15994 | Submission Open

Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy

(This special issue belongs to the Section Stem Cells)

Role of Alpha-Synuclein in Neurodegenerative Diseases

edited by

Carmela Conte

submission deadline 31 Aug 2026 | 3 articles | Viewed by 6994 | Submission Open

Keywords: Alpha-, Beta-, and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases

(This special issue belongs to the Section Cellular Aging)

Molecular Mechanisms Underlying Inflammatory Pain

edited by

Luke A. Pattison

submission deadline 31 Aug 2026 | 2 articles | Viewed by 5681 | Submission Open

Keywords: molecular mechanisms; inflammatory pain; nociception; neuronal sensitization; neuroimmune interactions

Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases

edited by Patricia Morcillo

submission deadline 31 Aug 2026 | 2 articles | Viewed by 5236 | Submission Open

Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers

(This special issue belongs to the Section Cellular Aging)

Inflammation and Aging in Acute and Chronic Kidney Injury

edited by

Massimiliano Migliori

Vincenzo Cantaluppi

and

Marita Marengo

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3476 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; inflammation; aging

(This special issue belongs to the Section Cellular Aging)

New Molecular Insights into Hepatitis and Hepatic Cancer

edited by

Mark A. Feitelson

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3293 | Submission Open

Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances

(This special issue belongs to the Section Cellular Pathology)

The Spatial and Temporal Dynamics of the Tumor Microenvironment

edited by

Shilpa Bisht

, Abhishek Gupta, Anjali Trivedi and

Alessandra Ferraresi

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2777 | Submission Open

Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor–immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches

(This special issue belongs to the Section Cell Microenvironment)

Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities

edited by Fabio Guolo

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2472 | Submission Open

Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers

(This special issue belongs to the Section Cellular Immunology)

Gene and Cell Therapy in Regenerative Medicine—Third Edition

edited by

Albert Rizvanov

and

Ayşegül Doğan

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2354 | Submission Open

Keywords: gene therapy; cell therapy; regenerative medicine; growth factors; stem cells

(This special issue belongs to the Section Cell and Gene Therapy)

Resolving Chronic Inflammation: Molecular Mechanisms, Cellular Signaling and Therapeutic Frontiers

edited by

Maria Anttonietta Panaro

and

Antonia Cianciulli

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2282 | Submission Open

Keywords: inflammatory mediators; cells polarization; apoptosis; epigenetic regulation; resolution pharmacology[EE2.1]; therapeutics

Lipoprotein and Cardiovascular Diseases Therapy

edited by Verity Ramirez and Wenliang Song

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1967 | Submission Open

Keywords: lipoprotein; cholesterol; cardiovascular disease; lipid-lowering therapy

(This special issue belongs to the Section Cells of the Cardiovascular System)

Molecular and Cellular Mechanisms of Ischemic Stroke

edited by Milani Deb-Chatterji

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1672 | Submission Open

Keywords: ischemic stroke; neuroinflammation; blood–brain barrier; neurovascular unit; molecular targets for stroke therapy

Cellular and Molecular Determinants of Inflammation: Immune Cell Function, Immunometabolism and Therapeutic Targeting

edited by Zenith Khashim and Quinn P. Peterson

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1638 | Submission Open

Keywords: inflammation; immune regulation; immunometabolism; immune cell function; organelle signaling; mitochondrial dynamics; extracellular vesicles; intercellular communication; tissue microenvironment; immune tolerance

(This special issue belongs to the Section Cellular Immunology)

From Inflammaging to Dementia: Cellular and Molecular Drivers of Cognitive Decline

edited by Michael P. McDonald and

Mohammad Moshahid Khan

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1520 | Submission Open

Keywords: neuroimmune crosstalk; brain-immune signaling; neuroinflammation; microglial activation; astrocytic reactivity; complement-mediated synaptic loss; cytokine modulation of synaptic plasticity; inflammasome signaling; blood–brain barrier dysfunction; neurovascular inflammation; immune-cell trafficking; synaptic dysfunction; biomarkers; DNA damage and repair; interferons responses; immune-targeted therapeutics; cognitive decline

(This special issue belongs to the Section Cellular Neuroscience)

Gastrointestinal Cancers: Research, Novel Diagnostic and Treatment Methods

edited by

Jens Hahne

and Michele Ghidini

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1286 | Submission Open

Keywords: gastrointestinal cancer; diagnostic; treatment options

(This special issue belongs to the Section Cellular Pathology)

Cellular Stress Responses in Early Embryonic and Stem Cell Development

edited by

Daniel Rappolee

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1141 | Submission Open

Keywords: early embryonic development; cellular stress responses; pluripotent stem cells; trophoblast biology; assisted reproductive technology (ART)

(This special issue belongs to the Section Stem Cells)

Comprehensive Advances in Eye Diseases: Cellular and Molecular Mechanisms, Pathophysiology and Translational Perspectives in Ophthalmic Research

edited by

Chi-Ming Chan

and Kai-Yang Chen

submission deadline 31 Aug 2026 | 1 articles | Viewed by 951 | Submission Open

Keywords: ophthalmic diseases; cellular mechanisms; molecular pathways; retinal degeneration; glial cells; neurovascular unit; oxidative stress; inflammation; translational research; therapeutic innovation

(This special issue belongs to the Section Cell Signaling)

Cellular Immunology at the Maternal–Fetal Interface

edited by

Tanya Dimova

submission deadline 31 Aug 2026 | 1 articles | Viewed by 795 | Submission Open

Keywords: leukocytes at MFI; cytotoxicity at MFI; trophoblast recognition via the KIR-HLA axis; decidualization and senescence of endometrial stromal cells; trophoblast invasion; spiral artery remodeling; tolerogenic molecules; exosomes in maternal–fetal communication; endometrial receptivity

(This special issue belongs to the Section Reproductive Cells and Development)

New Trends and Advances in Molecular Targeted Therapy for Cancers

edited by Dhivya Sridaran and

Jeremy M. Crook

submission deadline 31 Aug 2026 | Viewed by 641 | Submission Open

Keywords: cancer targeted therapy; antibodies; small-molecule inhibitors; antibody–drug conjugates; combination therapies

(This special issue belongs to the Section Cell and Gene Therapy)

Cellular and Molecular Signaling Pathways in Matrix Remodeling in COPD

edited by

Fernanda D.T.Q.S. Lopes

submission deadline 31 Aug 2026 | 1 articles | Viewed by 483 | Submission Open

Keywords: COPD; tissue remodeling; cellular and molecular signaling pathways; extracellular matrix components

(This special issue belongs to the Section Cell Signaling)

New Perspectives of Respiratory Diseases: From Microbiome, Metabolism, and Immune Response

edited by

Bernhard Ryffel

submission deadline 31 Aug 2026 | Viewed by 481 | Submission Open

Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors

Obesity and Metabolic Disease: Emerging Mechanisms, Inter-Organ Crosstalk and Translational Opportunities

edited by

Mangesh Hade

submission deadline 31 Aug 2026 | Viewed by 425 | Submission Open

Keywords: extracellular vesicles; exosomes; metabolic syndrome; obesity; insulin resistance; type 2 diabetes; cardiovascular disease; MAFLD; fatty liver; adipose tissue; microRNA; metabolic inflammation; inter-organ communication; biomarker; therapeutic EVs

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine

edited by Renata Kelly Da Palma

submission deadline 31 Aug 2026 | Viewed by 359 | Submission Open

Keywords: cell therapy; lung diseases; tissue regeneration

(This special issue belongs to the Section Tissues and Organs)

The Role of the Gene Expression and Regulation of the Pathogenesis of Oral Submucous Fibrosis

edited by

Sanjit Mukherjee

submission deadline 31 Aug 2026 | Viewed by 346 | Submission Open

Keywords: oral submucous fibrosis (OSMF); collagen deposition; epigenetic modifications; next-generation sequencing; oral cancer; progressive fibrosis

(This special issue belongs to the Section Cellular Pathology)

Recent Discoveries and Progress in Central Nervous System Neuroinflammation

edited by

Johannes Boltze

submission deadline 31 Aug 2026 | Viewed by 340 | Submission Open

Keywords: autoimmune; cerebrovascular; diagnosis; immune cells; microglia; neoplastic; neurodegenerative; neuroinflammation; system interaction; therapeutic targets

(This special issue belongs to the Section Cellular Neuroscience)

Advances in Cardiovascular Consequences of Diabetes and Obesity

edited by Priya Raman

submission deadline 31 Aug 2026 | Viewed by 321 | Submission Open

Keywords: diabetes; obesity; cardiovascular pathology; high glucose; dyslipidemia; adipokines; cardiometabolic dysfunction; therapeutic targets; chronic inflammation; lipotoxicity; glucotoxicity; mitochondrial dysfunction

(This special issue belongs to the Section Cells of the Cardiovascular System)

Targeted Therapeutic Strategies for Inborn Errors of Metabolism: Basic Mechanisms to Translational Research

edited by

Joseph G. Hacia

, Catherine Argyriou, Isha Srivastava and Christina Nemeth

submission deadline 31 Aug 2026 | Viewed by 294 | Submission Open

Keywords: inborn errors of metabolism; disease mechanisms; targeted therapies; gene therapy; small molecule therapy; oligonucleotide therapy; enzyme replacement therapy; mitochondrial disorders; lysosomal disorders; peroxisomal disorders

(This special issue belongs to the Section Cellular Pathology)

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