Cells 2014, 3(2), 199-235; doi:10.3390/cells3020199
Review

Role of Receptor Tyrosine Kinases and Their Ligands in Glioblastoma

Received: 18 December 2013; in revised form: 12 March 2014 / Accepted: 21 March 2014 / Published: 4 April 2014
(This article belongs to the Special Issue Receptor Tyrosine Kinases)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Glioblastoma multiforme is the most frequent, aggressive and fatal type of brain tumor. Glioblastomas are characterized by their infiltrating nature, high proliferation rate and resistance to chemotherapy and radiation. Recently, oncologic therapy experienced a rapid evolution towards “targeted therapy,” which is the employment of drugs directed against particular targets that play essential roles in proliferation, survival and invasiveness of cancer cells. A number of molecules involved in signal transduction pathways are used as molecular targets for the treatment of various tumors. In fact, inhibitors of these molecules have already entered the clinic or are undergoing clinical trials. Cellular receptors are clear examples of such targets and in the case of glioblastoma multiforme, some of these receptors and their ligands have become relevant. In this review, the importance of glioblastoma multiforme in signaling pathways initiated by extracellular tyrosine kinase receptors such as EGFR, PDGFR and IGF-1R will be discussed. We will describe their ligands, family members, structure, activation mechanism, downstream molecules, as well as the interaction among these pathways. Lastly, we will provide an up-to-date review of the current targeted therapies in cancer, in particular glioblastoma that employ inhibitors of these pathways and their benefits.
Keywords: RTK; EGFR; PDGFR; IGF-1R; glioblastoma multiforme
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MDPI and ACS Style

Carrasco-García, E.; Saceda, M.; Martínez-Lacaci, I. Role of Receptor Tyrosine Kinases and Their Ligands in Glioblastoma. Cells 2014, 3, 199-235.

AMA Style

Carrasco-García E, Saceda M, Martínez-Lacaci I. Role of Receptor Tyrosine Kinases and Their Ligands in Glioblastoma. Cells. 2014; 3(2):199-235.

Chicago/Turabian Style

Carrasco-García, Estefanía; Saceda, Miguel; Martínez-Lacaci, Isabel. 2014. "Role of Receptor Tyrosine Kinases and Their Ligands in Glioblastoma." Cells 3, no. 2: 199-235.

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