Cells 2014, 3(1), 53-78; doi:10.3390/cells3010053
Review

When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase

Received: 25 November 2013; in revised form: 14 January 2014 / Accepted: 20 January 2014 / Published: 27 January 2014
(This article belongs to the Special Issue Receptor Tyrosine Kinases)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Overexpression and activation of ErbB2 receptor tyrosine kinase in breast cancer is strongly linked to an aggressive disease with high potential for invasion and metastasis. In addition to inducing very aggressive, metastatic cancer, ErbB2 activation mediates processes such as increased cancer cell proliferation and survival and is needed for normal physiological activities, such as heart function and development of the nervous system. How does ErbB2 activation make cancer cells invasive and when? Comprehensive understanding of the cellular mechanisms leading to ErbB2-induced malignant processes is necessary for answering these questions. Here we present current knowledge about the invasion-promoting function of ErbB2 and the mechanisms involved in it. Obtaining detailed information about the “bad” behavior of ErbB2 can facilitate development of novel treatments against ErbB2-positive cancers.
Keywords: cathepsin B; cathepsin L; matrix metalloprotease; p95 ErbB2; p21-activated protein kinase; transforming growth factor β
PDF Full-text Download PDF Full-Text [529 KB, Updated Version, uploaded 29 January 2014 10:24 CET]
The original version is still available [737 KB, uploaded 27 January 2014 19:11 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Brix, D.M.; Clemmensen, K.K.B.; Kallunki, T. When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase. Cells 2014, 3, 53-78.

AMA Style

Brix DM, Clemmensen KKB, Kallunki T. When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase. Cells. 2014; 3(1):53-78.

Chicago/Turabian Style

Brix, Ditte M.; Clemmensen, Knut K.B.; Kallunki, Tuula. 2014. "When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase." Cells 3, no. 1: 53-78.

Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert