Special Issue "Cellular Interactions of the Cytolethal Distending Toxins"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 April 2014)
Dr. Teresa Frisan
Department Cell and Molecular Biology (CMB), Berzelius väg 35, Box 285, S-171 77 Stockholm, Sweden
Phone: +46 8 524 863 85
Interests: bacteria and cancer; host-microbe interaction; bacterial genotoxins; DNA damage response; carcinogenesis; bacteria and bacterial toxins internalization and intracellular trafficking
An emerging feature in commensal and pathogenic bacteria is the production of genotoxins, which are able to induce DNA damage in the target cells. The first family of bacterial genotoxins described is the cytolethal distending toxin (CDT). The discovery of this novel type of protein toxins has given a new perspective to the field of cellular microbiology, ranging from the characterization of the toxin internalization and intracellular trafficking, since this was the first bacterial protein toxin that needed to be translocated to the nuclear compartment, to the understanding of the chronic effects of cellular intoxication in term of acquisition of carcinogenic traits, such as genomic instability.
This special issue aims to provide the state of the art of several aspects of the CDTs biology, such as internalization and intracellular trafficking, cellular effects of intoxication in vitro, the consequences of acute and chronic infection with CDT-producing bacteria in in vivo models, as well as epidemiological studies linking CDT with specific diseases.
Dr. Teresa Frisan
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- toxin internalization
- intracellular trafficking
- cellular responses
- in vivo models
- genotoxic stress