Special Issue "Cellular Interactions of the Cytolethal Distending Toxins"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 April 2014)
Dr. Teresa Frisan
Department Cell and Molecular Biology (CMB), Berzelius väg 35, Box 285, S-171 77 Stockholm, Sweden
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Phone: (+46) 8 5248 6385
Interests: bacteria and cancer; host-microbe interaction; bacterial genotoxins; DNA damage response; carcinogenesis; bacteria and bacterial toxins internalization and intracellular trafficking
An emerging feature in commensal and pathogenic bacteria is the production of genotoxins, which are able to induce DNA damage in the target cells. The first family of bacterial genotoxins described is the cytolethal distending toxin (CDT). The discovery of this novel type of protein toxins has given a new perspective to the field of cellular microbiology, ranging from the characterization of the toxin internalization and intracellular trafficking, since this was the first bacterial protein toxin that needed to be translocated to the nuclear compartment, to the understanding of the chronic effects of cellular intoxication in term of acquisition of carcinogenic traits, such as genomic instability.
This special issue aims to provide the state of the art of several aspects of the CDTs biology, such as internalization and intracellular trafficking, cellular effects of intoxication in vitro, the consequences of acute and chronic infection with CDT-producing bacteria in in vivo models, as well as epidemiological studies linking CDT with specific diseases.
Dr. Teresa Frisan
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- toxin internalization
- intracellular trafficking
- cellular responses
- in vivo models
- genotoxic stress
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Inflammatory and Bone Remodeling Responses to the Cytolethal Distending Toxins
Authors: Georgios N. Belibasakis 1,* and Nagihan Bostanci 2
Affiliations: 1 Oral Microbiology and Immunology, Institute of Oral Biology, Center of Dental Medicine, University of Zürich, Plattenstrasse 11, 8032 Zürich, Switzerland; E-Mail: George.Belibasakis@zzm.uzh.ch; Tel.: +41-446-343-306; Fax: +41-446-343-310.
2 Oral Translational Research, Institute of Oral Biology, Center of Dental Medicine, University of Zürich, Plattenstrasse 11, 8032 Zürich, Switzerland; E-Mail: Nagihan.Bostanci@zzm.uzh.ch
Abstract: The cytolethal distending toxins (CDTs) are a family of exotoxins produced by a wide range of unrelated to each other Gram-negative bacteria. They are known for causing genotoxic stress to the cell, resulting in growth arrest and eventually apoptotic cell death. Nevertheless, there is evidence that CDTs can also perturb the innate immune responses, by regulating inflammatory cytokine production and molecular mediators of bone remodeling in various cell types. These cellular and molecular events may in turn have an effect in enhancing local inflammation in diseases where CDT-producing bacteria are involved. One special example is the induction of pathological bone destruction in the clinical condition of periodontitis. The opportunistic oral pathogen Aggregatibatcer actinoycemetemcomitans, which is involved in the aggressive form of the disease, can regulate the molecular mechanisms of bone remodeling in a manner that favors bone resorption, attributed to its CDT. The present review provides an overview of all known to-date inflammatory or bone remodeling responses of CDTs produced by various bacterial species, and discusses their potential contribution to the pathogenesis of the associated diseases.
Keywords: cytolethal distending toxin; cytokine; inflammation; bone remodeling; immune response; Aggregatibacter actinomycetemcomitans