The Signal-Processing in Tumor
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 30647
Special Issue Editors
Interests: personalized precision medicine; pathway targeted drugs; tumor cell signaling
Special Issues, Collections and Topics in MDPI journals
2. Consultant, VieCure, Greenwood Village, CO, USA
Interests: genomics-driven treatment approach in n-of-1 format; tailored immune-therapy; PI3K-mTOR pathway
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tumors and their ecosystems co-evolve over time, leading to genomic alterations within tumor cells; thus, anti-tumor treatment must be adapted over the course of the disease. To better understand this process and its mechanisms: How does signal transduction in tumors cells shape the tumor ecosystem? Tumor cells send and receive bidirectional signals to and from adjacent tumor cells as well as the tumor microenvironment, endothelium, immune cells, and fibroblasts. Via this exchange of signals, tumor cells control their stromal milieu to sustain their growth, evolve, respond to drugs, and advance. Thus, signal transduction pathways play key roles in initiation, progression, and metastasis processes. These pathways, which control normal cell growth, are frequently disrupted and altered in cancer cells. Cells that have abnormal signaling molecules may become cancer cells. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. This leads to genetic changes, epigenetic alterations, mutations, chromosomal rearrangement, and protein overexpression/phosphorylation (post-translational modification with selectivity for cells with a high proliferative capacity, survival, invasion, and metastasis). It is now known that there is a variety of signal transduction methods and pathways in cells, which engage in multiple levels of cross-talk, constituting a very complicated network. The choreographic language of these signals is the fundamental basis of treatment approaches in cancer management.
Dr. Nandini Dey
Dr. Pradip De
Guest Editors
Manuscript Submission Information
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