Special Issue "Lung Cancer"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (30 December 2010)
Prof. Dr. Gerolama Condorelli
Department of Cellular and Molecular Biology and Pathology, Istituto di Endocrinologia e Oncologia Sperimentale ‘‘G. Salvatore’’-Consiglio Nazionale delle Ricerche, Faculty of Biotechnological Science, ‘‘Federico II’’ University of Naples, I-80121 Naples, Italy
Interests: apoptosis; cell death; TRAIL; microRNA; cell motility; chemotherapy resistance
Lung cancer is the leading cause of cancer death in both men and women worldwide. It is becoming apparent, through candidate gene and genome-wide approaches, that clinically evident lung cancers accumulate numerous clonal genetic and epigenetic alterations during a multistep process. These alterations include tumor suppressor gene inactivation and activation of growth or survival promoting oncogenes.
Despite advances in early detection and standard treatment, lung cancer is often diagnosed at an advanced stage and have poor prognoses. The development of innovative, targeted therapies may represent an alternative for the treatment of these cancers.
One of the most important factors that affect survival rate is resistance to therapeutic drugs. Thus development of effective therapeutic approaches is necessary for the management of these common cancers. MiRNAs are attractive drug targets since they regulate expression of many cellular proteins and are differentially
MicroRNAs are small noncoding RNAs that show expression loss or gain in most cancers, and there is growing evidence that they play substantial roles in the pathogenesis and prognosis of human malignancies.
The central focus of the special issue on “Lung Cancer” is identification of molecular pathways involved in lung tumorigenesis and therapeutic resistance. The main topics will include, but are not limited to, the role of cell death (e.g., apoptosis and necrosis) and cell survival pathways (e.g., autophagy) in tumorigenesis and chemotherapy resistance; role microRNAs and their targets in lung prognosis, diagnosis and response to therapy.
Thank you for your collaboration.
Prof. Dr. Gerolama Condorelli
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- lung cancer
- cell death
- cell survival
- death receptors
- tumor suppressor genes
Cancers 2010, 2(4), 1813-1829; doi:10.3390/cancers2041813
Received: 15 September 2010; in revised form: 15 October 2010 / Accepted: 24 October 2010 / Published: 28 October 2010| Download PDF Full-text (238 KB) | Download XML Full-text
Article: Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice
Cancers 2010, 2(4), 2153-2170; doi:10.3390/cancers2042153
Received: 20 October 2010; in revised form: 25 November 2010 / Accepted: 21 December 2010 / Published: 22 December 2010| Download PDF Full-text (1363 KB) | Download XML Full-text | Correction
Cancers 2011, 3(1), 789-801; doi:10.3390/cancers3010789
Received: 30 December 2010; in revised form: 9 February 2011 / Accepted: 15 February 2011 / Published: 23 February 2011| Download PDF Full-text (420 KB) | Download XML Full-text
Cancers 2011, 3(1), 1014-1041; doi:10.3390/cancers3011014
Received: 31 December 2010; in revised form: 20 February 2011 / Accepted: 1 March 2011 / Published: 3 March 2011| Download PDF Full-text (373 KB) | Download XML Full-text
Review: Analysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases
Cancers 2011, 3(1), 1195-1231; doi:10.3390/cancers3011195
Received: 7 January 2011; in revised form: 28 February 2011 / Accepted: 1 March 2011 / Published: 10 March 2011| Download PDF Full-text (871 KB) | Download XML Full-text
Cancers 2011, 3(1), 1426-1453; doi:10.3390/cancers3011426
Received: 29 December 2010; in revised form: 9 March 2011 / Accepted: 10 March 2011 / Published: 17 March 2011| Download PDF Full-text (308 KB) | Download XML Full-text
Cancers 2011, 3(2), 1861-1876; doi:10.3390/cancers3021861
Received: 4 January 2011; in revised form: 18 March 2011 / Accepted: 31 March 2011 / Published: 1 April 2011| Download PDF Full-text (188 KB) | Download XML Full-text
Cancers 2011, 3(2), 2333-2357; doi:10.3390/cancers3022333
Received: 7 March 2011; in revised form: 28 April 2011 / Accepted: 3 May 2011 / Published: 11 May 2011| Download PDF Full-text (286 KB) | Download XML Full-text
Review: The Role of Epidermal Growth Factor Receptor Mutations and Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in the Treatment of Lung Cancer
Cancers 2011, 3(2), 2667-2678; doi:10.3390/cancers3022667
Received: 28 April 2011; in revised form: 1 June 2011 / Accepted: 7 June 2011 / Published: 10 June 2011| Download PDF Full-text (198 KB) | Download XML Full-text
Review: Sputum-Based Molecular Biomarkers for the Early Detection of Lung Cancer: Limitations and Promise
Cancers 2011, 3(3), 2975-2989; doi:10.3390/cancers3032975
Received: 3 June 2011; in revised form: 11 July 2011 / Accepted: 12 July 2011 / Published: 19 July 2011| Download PDF Full-text (250 KB) | Download XML Full-text
Review: NF-kappaB in Lung Tumorigenesis
Cancers 2011, 3(4), 4258-4268; doi:10.3390/cancers3044258
Received: 13 October 2011; in revised form: 29 November 2011 / Accepted: 6 December 2011 / Published: 14 December 2011| Download PDF Full-text (101 KB) | Download XML Full-text
Last update: 25 September 2012