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Cancers 2011, 3(1), 789-801; doi:10.3390/cancers3010789
Article

Mastic Oil Inhibits the Metastatic Phenotype of Mouse Lung Adenocarcinoma Cells

1,* , 1
, 2
 and 1
Received: 30 December 2010; in revised form: 9 February 2011 / Accepted: 15 February 2011 / Published: 23 February 2011
(This article belongs to the Special Issue Lung Cancer)
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Abstract: Mastic oil from Pistacia lentiscus variation chia, a natural combination of bioactive terpenes, has been shown to exert anti-tumor growth effects against a broad spectrum of cancers including mouse Lewis lung adenocarcinomas (LLC). However, no studies have addressed its anti-metastatic actions. In this study, we showed that treatment of LLC cells with mastic oil within a range of non-toxic concentrations (0.01–0.04% v/v): (a) abrogated their Matrigel invasion and migration capabilities in transwell assays; (b) reduced the levels of secreted MMP-2; (c) restricted phorbol ester-induced actin remodeling and (d) limited the length of neo-vessel networks in tumor microenvironment in the model of chick embryo chorioallantoic membrane. Moreover, exposure of LLC and endothelial cells to mastic oil impaired their adhesive interactions in a co-culture assay and reduced the expression of key adhesion molecules by endothelial cells upon their stimulation with tumor necrosis factor-alpha. Overall, this study provides novel evidence supporting a multipotent role for mastic oil in prevention of crucial processes related to cancer metastasis.
Keywords: lung cancer; prevention; mastic plant essential oil; invasion; motility; adhesion; angiogenesis lung cancer; prevention; mastic plant essential oil; invasion; motility; adhesion; angiogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Loutrari, H.; Magkouta, S.; Papapetropoulos, A.; Roussos, C. Mastic Oil Inhibits the Metastatic Phenotype of Mouse Lung Adenocarcinoma Cells. Cancers 2011, 3, 789-801.

AMA Style

Loutrari H, Magkouta S, Papapetropoulos A, Roussos C. Mastic Oil Inhibits the Metastatic Phenotype of Mouse Lung Adenocarcinoma Cells. Cancers. 2011; 3(1):789-801.

Chicago/Turabian Style

Loutrari, Heleni; Magkouta, Sophia; Papapetropoulos, Andreas; Roussos, Charis. 2011. "Mastic Oil Inhibits the Metastatic Phenotype of Mouse Lung Adenocarcinoma Cells." Cancers 3, no. 1: 789-801.



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