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Cancers 2011, 3(1), 789-801; doi:10.3390/cancers3010789
Article

Mastic Oil Inhibits the Metastatic Phenotype of Mouse Lung Adenocarcinoma Cells

1,* , 1
,
2
 and
1
1 “G.P. Livanos and M. Simou Laboratories”, Evangelismos Hospital, Department of Critical Care and Pulmonary Services, School of Medicine, University of Athens, 3 Ploutarchou Street, 10675 Athens, Greece 2 Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece
* Author to whom correspondence should be addressed.
Received: 30 December 2010 / Revised: 9 February 2011 / Accepted: 15 February 2011 / Published: 23 February 2011
(This article belongs to the Special Issue Lung Cancer)
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Abstract

Mastic oil from Pistacia lentiscus variation chia, a natural combination of bioactive terpenes, has been shown to exert anti-tumor growth effects against a broad spectrum of cancers including mouse Lewis lung adenocarcinomas (LLC). However, no studies have addressed its anti-metastatic actions. In this study, we showed that treatment of LLC cells with mastic oil within a range of non-toxic concentrations (0.01–0.04% v/v): (a) abrogated their Matrigel invasion and migration capabilities in transwell assays; (b) reduced the levels of secreted MMP-2; (c) restricted phorbol ester-induced actin remodeling and (d) limited the length of neo-vessel networks in tumor microenvironment in the model of chick embryo chorioallantoic membrane. Moreover, exposure of LLC and endothelial cells to mastic oil impaired their adhesive interactions in a co-culture assay and reduced the expression of key adhesion molecules by endothelial cells upon their stimulation with tumor necrosis factor-alpha. Overall, this study provides novel evidence supporting a multipotent role for mastic oil in prevention of crucial processes related to cancer metastasis.
Keywords: lung cancer; prevention; mastic plant essential oil; invasion; motility; adhesion; angiogenesis lung cancer; prevention; mastic plant essential oil; invasion; motility; adhesion; angiogenesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Loutrari, H.; Magkouta, S.; Papapetropoulos, A.; Roussos, C. Mastic Oil Inhibits the Metastatic Phenotype of Mouse Lung Adenocarcinoma Cells. Cancers 2011, 3, 789-801.

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