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Cancers 2011, 3(2), 1861-1876; doi:10.3390/cancers3021861

Molecular Epidemiology of Female Lung Cancer

Received: 4 January 2011 / Revised: 18 March 2011 / Accepted: 31 March 2011 / Published: 1 April 2011
(This article belongs to the Special Issue Lung Cancer)
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Lung cancer is still a leading cause of cancer mortality in the world. The incidence of lung cancer in developed countries started to decrease mainly due to global anti-smoking campaigns. However, the incidence of lung cancer in women has been increasing in recent decades for various reasons. Furthermore, since the screening of lung cancer is not as yet very effective, clinically applicable molecular markers for early diagnosis are much required. Lung cancer in women appears to have differences compared with that in men, in terms of histologic types and susceptibility to environmental risk factors. This suggests that female lung cancer can be derived by carcinogenic mechanisms different from those involved in male lung cancer. Among female lung cancer patients, many are non-smokers, which could be studied to identify alternative carcinogenic mechanisms independent from smoking-related ones. In this paper, we reviewed molecular susceptibility markers and genetic changes in lung cancer tissues observed in female lung cancer patients, which have been validated by various studies and will be helpful to understand the tumorigenesis of lung cancer.
Keywords: female lung cancer; sex difference; genetic susceptibility; SNP; smoking female lung cancer; sex difference; genetic susceptibility; SNP; smoking
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yim, S.-H.; Chung, Y.-J. Molecular Epidemiology of Female Lung Cancer. Cancers 2011, 3, 1861-1876.

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