- freely available
NF-kappaB in Lung Tumorigenesis
AbstractThe development of lung cancer in humans can be divided into three steps: initiation, promotion and progression. This process is driven by alterations in related signal transduction pathways. These pathways signal the aberrant activation of NF-kappaB, a transcription factor that regulates the expression of genes important for lung tumorigenesis. Our current knowledge about the role of the NF-kappaB signaling pathway in the development of lung cancer has been bolstered by animal models demonstrating the connection between K-ras and tobacco induced lung transformation with NF-kappaB. Activation of downstream genes leads to cell proliferation, inhibition of apoptosis, angiogenesis, inflammation, invasion, and metastasis.
Share & Cite This Article
Cai, Z.; Tchou-Wong, K.-M.; Rom, W.N. NF-kappaB in Lung Tumorigenesis. Cancers 2011, 3, 4258-4268.View more citation formats
Cai Z, Tchou-Wong K-M, Rom WN. NF-kappaB in Lung Tumorigenesis. Cancers. 2011; 3(4):4258-4268.Chicago/Turabian Style
Cai, Zhenjian; Tchou-Wong, Kam-Meng; Rom, William N. 2011. "NF-kappaB in Lung Tumorigenesis." Cancers 3, no. 4: 4258-4268.