Cancers 2011, 3(4), 4258-4268; doi:10.3390/cancers3044258
Review

NF-kappaB in Lung Tumorigenesis

1email, 1,2email and 1,2,* email
Received: 13 October 2011; in revised form: 29 November 2011 / Accepted: 6 December 2011 / Published: 14 December 2011
(This article belongs to the Special Issue Lung Cancer)
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Abstract: The development of lung cancer in humans can be divided into three steps: initiation, promotion and progression. This process is driven by alterations in related signal transduction pathways. These pathways signal the aberrant activation of NF-kappaB, a transcription factor that regulates the expression of genes important for lung tumorigenesis. Our current knowledge about the role of the NF-kappaB signaling pathway in the development of lung cancer has been bolstered by animal models demonstrating the connection between K-ras and tobacco induced lung transformation with NF-kappaB. Activation of downstream genes leads to cell proliferation, inhibition of apoptosis, angiogenesis, inflammation, invasion, and metastasis.
Keywords: NF-kappaB; lung cancer; tumorigenesis; tumor initiation; tumor promotion; tumor progression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cai, Z.; Tchou-Wong, K.-M.; Rom, W.N. NF-kappaB in Lung Tumorigenesis. Cancers 2011, 3, 4258-4268.

AMA Style

Cai Z, Tchou-Wong K-M, Rom WN. NF-kappaB in Lung Tumorigenesis. Cancers. 2011; 3(4):4258-4268.

Chicago/Turabian Style

Cai, Zhenjian; Tchou-Wong, Kam-Meng; Rom, William N. 2011. "NF-kappaB in Lung Tumorigenesis." Cancers 3, no. 4: 4258-4268.



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