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NF-kappaB in Lung Tumorigenesis
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, 462 First Avenue, NBV 7N24, New York, NY 10016, USA
Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
* Author to whom correspondence should be addressed.
Received: 13 October 2011; in revised form: 29 November 2011 / Accepted: 6 December 2011 / Published: 14 December 2011
(This article belongs to the Special Issue Lung Cancer
Abstract: The development of lung cancer in humans can be divided into three steps: initiation, promotion and progression. This process is driven by alterations in related signal transduction pathways. These pathways signal the aberrant activation of NF-kappaB, a transcription factor that regulates the expression of genes important for lung tumorigenesis. Our current knowledge about the role of the NF-kappaB signaling pathway in the development of lung cancer has been bolstered by animal models demonstrating the connection between K-ras and tobacco induced lung transformation with NF-kappaB. Activation of downstream genes leads to cell proliferation, inhibition of apoptosis, angiogenesis, inflammation, invasion, and metastasis.
Keywords: NF-kappaB; lung cancer; tumorigenesis; tumor initiation; tumor promotion; tumor progression
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Cite This Article
MDPI and ACS Style
Cai, Z.; Tchou-Wong, K.-M.; Rom, W.N. NF-kappaB in Lung Tumorigenesis. Cancers 2011, 3, 4258-4268.
Cai Z, Tchou-Wong K-M, Rom WN. NF-kappaB in Lung Tumorigenesis. Cancers. 2011; 3(4):4258-4268.
Cai, Zhenjian; Tchou-Wong, Kam-Meng; Rom, William N. 2011. "NF-kappaB in Lung Tumorigenesis." Cancers 3, no. 4: 4258-4268.