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Targets and Mechanisms of Photodynamic Therapy in Lung Cancer Cells: A Brief Overview
Department of Biologia e Patologia Cellulare e Molecolare “L. Califano” - Università Federico II, Via S. Pansini, 5 80131 Naples, Italy
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 31 December 2010; in revised form: 20 February 2011 / Accepted: 1 March 2011 / Published: 3 March 2011
(This article belongs to the Special Issue Lung Cancer
Abstract: Lung cancer remains one of the most common cancer-related causes of death. This type of cancer typically develops over a period of many years, and if detected at an early enough stage can be eliminated by a variety of treatments including photodynamic therapy (PDT). A critical discussion on the clinical applications of PDT in lung cancer is well outside the scope of the present report, which, in turn focuses on mechanistic and other aspects of the photodynamic action at a molecular and cellular level. The knowledge of these issues at pre-clinical levels is necessary to develop, check and adopt appropriate clinical protocols in the future. This report, besides providing general information, includes a brief overview of present experimental PDT and provides some non-exhaustive information on current strategies aimed at further improving the efficacy, especially in regard to lung cancer cells.
Keywords: photodynamic therapy; photosensitizers; lung cancer cells
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MDPI and ACS Style
Chiaviello, A.; Postiglione, I.; Palumbo, G. Targets and Mechanisms of Photodynamic Therapy in Lung Cancer Cells: A Brief Overview. Cancers 2011, 3, 1014-1041.
Chiaviello A, Postiglione I, Palumbo G. Targets and Mechanisms of Photodynamic Therapy in Lung Cancer Cells: A Brief Overview. Cancers. 2011; 3(1):1014-1041.
Chiaviello, Angela; Postiglione, Ilaria; Palumbo, Giuseppe. 2011. "Targets and Mechanisms of Photodynamic Therapy in Lung Cancer Cells: A Brief Overview." Cancers 3, no. 1: 1014-1041.