Cancers 2011, 3(1), 1426-1453; doi:10.3390/cancers3011426
Review

The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer

Trinity College Dublin, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James Hospital, James Street, Dublin 8, Ireland
* Author to whom correspondence should be addressed.
Received: 29 December 2010; in revised form: 9 March 2011 / Accepted: 10 March 2011 / Published: 17 March 2011
(This article belongs to the Special Issue Lung Cancer)
PDF Full-text Download PDF Full-Text [308 KB, uploaded 17 March 2011 12:26 CET]
Abstract: Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, usually combined with drugs such as gemcitabine or pemetrexed, induce objective tumor responses in only 20–30% of patients. Aberrant epigenetic regulation of gene expression is a frequent event in NSCLC. In this article we review the emerging evidence that epigenetics and the cellular machinery involved with this type of regulation may be key elements in the development of cisplatin resistance in NSCLC.
Keywords: epigenetics; histone; post-translational modification; DNA methylation; epigenetic modifiers; cisplatin; NSCLC

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

O’Byrne, K.J.; Barr, M.P.; Gray, S.G. The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer. Cancers 2011, 3, 1426-1453.

AMA Style

O’Byrne KJ, Barr MP, Gray SG. The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer. Cancers. 2011; 3(1):1426-1453.

Chicago/Turabian Style

O’Byrne, Kenneth J.; Barr, Martin P.; Gray, Steven G. 2011. "The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer." Cancers 3, no. 1: 1426-1453.

Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert