Special Issue "Exploring the Mechanisms by which α-Synuclein Kills Cells in Parkinson Disease"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (15 March 2015)
Prof. Dr. Stephan N. Witt
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130-3932, USA
Website | E-Mail
Fax: +1 318 675 5180
Interests: α-synuclein; Parkinson’s disease; endoplasmic reticulum stress; lipid homeostasis; neurodegeneration
α-Synuclein (α-syn) is a small protein that is highly expressed in dopaminergic neurons, where it is thought to regulate fusion of presynaptic vesicles with the presynaptic membrane. Monomeric α-syn is intrinsically unfolded in solution but α-helical when membrane-bound. At elevated concentrations, α-synuclein self-associates into soluble oligomers or deposits into insoluble β-amyloid fibers. Soluble tetrameric forms also probably exist in cells. Many researchers are convinced that the soluble oligomeric forms of α-syn kill cells. One question is: what cellular environment triggers α-syn to convert from a non-toxic protein into a toxic one? Another question is: how does α-syn kills cells?
We encourage scientists of diverse backgrounds (biophysical, cell biology, and animal models) and that use different model systems (yeast, fly, worm, rodents, human cells) to contribute original research or review articles that focus on the cellular conditions that promote α-syn to become toxic or the mechanisms by which α-syn kills cells.
Prof. Dr. Stephan N. Witt
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- calcium homeostasis
- lipid homeostasis