Next Article in Journal
Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis
Next Article in Special Issue
Is Cell Death Primary or Secondary in the Pathophysiology of Idiopathic Parkinson’s Disease?
Previous Article in Journal
New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel
Previous Article in Special Issue
Interaction between Neuromelanin and Alpha-Synuclein in Parkinson’s Disease
Article Menu

Export Article

Open AccessReview
Biomolecules 2015, 5(3), 1210-1227; doi:10.3390/biom5031210

Synthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational Modifications

1
Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA
2
Department of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Stephan N. Witt
Received: 17 March 2015 / Revised: 17 May 2015 / Accepted: 9 June 2015 / Published: 25 June 2015
View Full-Text   |   Download PDF [3205 KB, uploaded 25 June 2015]   |  

Abstract

α-Synuclein is the aggregation-prone protein associated with Parkinson’s disease (PD) and related neurodegenerative diseases. Complicating both its biological functions and toxic aggregation are a variety of posttranslational modifications. These modifications have the potential to either positively or negatively affect α-synuclein aggregation, raising the possibility that the enzymes that add or remove these modifications could be therapeutic targets in PD. Synthetic protein chemistry is uniquely positioned to generate site-specifically and homogeneously modified proteins for biochemical study. Here, we review the application of synthetic peptides and proteins towards understanding the effects of α-synuclein posttranslational modifications. View Full-Text
Keywords: Synuclein; posttranslational modifications; synthesis Synuclein; posttranslational modifications; synthesis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Pratt, M.R.; Abeywardana, T.; Marotta, N.P. Synthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational Modifications. Biomolecules 2015, 5, 1210-1227.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top