Special Issue "Obesity and Hormones"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 31 December 2018

Special Issue Editor

Guest Editor
Dr. Srinivas Nammi

School of Science and Health, Western Sydney University, Australia
Website | E-Mail
Interests: obesity; metabolic syndrome; diabetes; dyslipidaemia; fatty liver disease; chronic kidney disease

Special Issue Information

Dear Colleagues,

Obesity is a complex multi-factorial chronic medical condition characterized by overweight with excess or abnormal body fat accumulation. It is considered as a strong risk factor in the development of serious diseases, such as type 2 diabetes, hypertension, cardiovascular disease, stroke, gastrointestinal disorders, and certain cancers. In general, obesity is caused by increased intake of energy rich foods and/or decreased exercise and physical activity. Among the genetic factors, hormonal imbalance as a cause and consequence of obesity play a role with adverse health effects of obesity. Several hormones, including insulin, leptin, sex hormones and growth hormone, have been studied extensively and play a role in appetite, metabolism, body fat distribution and increased storage of excess energy as fats. Thus, excess or deficit of hormones leads to obesity and, on the other hand, obesity also results in changes in certain hormones that contribute to the adverse metabolic effects of obesity leading to life-threatening chronic diseases. Although past research in understanding the etiology of hormonal imbalance as a cause of obesity, recent technological and analytical advances have enabled detection of a number of obesity susceptible genes involved in the regulation of food intake and in adipocyte function. These results provide plausible biological pathways that may be targeted in the future as part of treatment or prevention strategies.

We invite scientists to contribute both original research articles or reviews covering studies on hormonal intervention on obesity and its complications. Both basic and translational research papers are welcome.

Dr. Srinivas Nammi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • leptin
  • insulin
  • estrogens
  • androgens
  • growth hormone

Published Papers (1 paper)

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Research

Open AccessCommunication Simple Analysis of Lipid Inhibition Activity on an Adipocyte Micro-Cell Pattern Chip
Biomolecules 2018, 8(2), 37; https://doi.org/10.3390/biom8020037
Received: 5 April 2018 / Revised: 25 May 2018 / Accepted: 31 May 2018 / Published: 4 June 2018
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Abstract
Polydimethyl-siloxane (PDMS) is often applied to fabricate cell chips. In this study, we fabricated an adipocyte microcell pattern chips using PDMS to analyze the inhibition activity of lipid droplets in mouse embryo fibroblast cells (3T3-L1) with anti-obesity agents. To form the PDMS based
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Polydimethyl-siloxane (PDMS) is often applied to fabricate cell chips. In this study, we fabricated an adipocyte microcell pattern chips using PDMS to analyze the inhibition activity of lipid droplets in mouse embryo fibroblast cells (3T3-L1) with anti-obesity agents. To form the PDMS based micropattern, we applied the micro-contact printing technique using PDMS micro-stamps that had been fabricated by conventional soft lithography. This PDMS micro-pattern enabled the selective growth of 3T3-L1 cells onto the specific region by preventing cell adhesion on the PDMS region. It then allowed growth of the 3T3-L1 cells in the chip for 10 days and confirmed that lipid droplets were formed in the 3T3-L1 cells. After treatment of orlistat and quercetin were treated in an adipocyte micro-cell pattern chip with 3T3-L1 cells for six days, we found that orlistat and quercetin exhibited fat inhibition capacities of 19.3% and 24.4% from 0.2 μM of lipid droplets in 3T3-L1 cells. In addition, we conducted a direct quantitative analysis of 3T3-L1 cell differentiation using Oil Red O staining. In conclusion, PDMS-based adipocyte micro-cell pattern chips may contribute to the development of novel bioactive compounds. Full article
(This article belongs to the Special Issue Obesity and Hormones)
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