Superiority of the Non-Glycosylated Form over the Glycosylated Form of Irisin in the Attenuation of Adipocytic Meta-Inflammation: A Potential Factor in the Fight against Insulin Resistance
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chemicals and Materials
2.2. Cell Coculture and Experimental Design
2.3. Cell Activity and Viability
2.4. Quantitative Real-Time PCR Assay
2.5. Examination of Cytokine and Adipokine Release
2.6. Macrophage Migration
2.7. Statistical Analysis
3. Results
3.1. Overall Activity and Viability of Cell Coculture
3.2. Cytokine Production Was More Strongly Inhibited by the Non-Glycosylated Form of Irisin
3.3. Both Forms of Irisin Similarly Inhibited the Production of Adipokines
3.4. Non-Glycosylated Form of Irisin Inhibited Macrophage Migration
4. Discussion
5. Conclusions
Funding
Conflicts of Interest
References
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Mazur-Bialy, A.I. Superiority of the Non-Glycosylated Form over the Glycosylated Form of Irisin in the Attenuation of Adipocytic Meta-Inflammation: A Potential Factor in the Fight against Insulin Resistance. Biomolecules 2019, 9, 394. https://doi.org/10.3390/biom9090394
Mazur-Bialy AI. Superiority of the Non-Glycosylated Form over the Glycosylated Form of Irisin in the Attenuation of Adipocytic Meta-Inflammation: A Potential Factor in the Fight against Insulin Resistance. Biomolecules. 2019; 9(9):394. https://doi.org/10.3390/biom9090394
Chicago/Turabian StyleMazur-Bialy, Agnieszka Irena. 2019. "Superiority of the Non-Glycosylated Form over the Glycosylated Form of Irisin in the Attenuation of Adipocytic Meta-Inflammation: A Potential Factor in the Fight against Insulin Resistance" Biomolecules 9, no. 9: 394. https://doi.org/10.3390/biom9090394