Special Issue "Cell Penetrating Peptides"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (15 June 2018)

Special Issue Editor

Guest Editor
Prof. Dr. Jean-Philippe Pellois

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA
Website | E-Mail
Interests: protein engineering; membrane biochemistry; peptide/membrane interactions; cellular trafficking

Special Issue Information

Dear Colleagues, 

By having the ability to cross membranes, cell-penetrating peptides (CPPs) can enter cells and modulate cell physiology. CPPs can also serve as carriers that can deliver various macromolecules into cells. Consequently, CPPs are used in a wide array of applications with basic science, biotechnological, and therapeutic purposes. For instance, CPPs have been used to disrupt protein–protein interactions and modulate signal transduction pathways, to deliver nucleic acids to affect gene expression, to deliver fluorescent particles for microscopy-based investigations, to deliver transcription factors for cellular reprogramming, or to deliver radioisotopically-labeled proteins for in cellulo structure determination by NMR.   

By changing our views on what can and cannot enter a cell, CPPs have expanded the scope of what can be potentially done to manipulate or probe cells. They are also contributing to changing the notion of what may constitute a drug or a drug target. Concomitantly, they have also raised many questions. How do they enter cells? What do they do to cells, from the outside, at cellular membranes, and once inside the cell? What are the chemical and structural features that are required to achieve cell permeability? How can the efficiencies of cell targeting, endocytic uptake, or cytosolic penetration be increased? How can their properties be tuned to minimize cellular damage that may result from their membrane-disruption activities? Answering these questions remains an area of intense and exciting research, both in academia and in industry.

We invite scientist focusing on understanding, optimizing, and using CPPs to submit their original work or reviews. Both translational and basic research papers are welcome.

Prof. Dr. Jean-Philippe Pellois
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cell penetrating peptide
  • membrane translocation
  • drug delivery
  • cellular trafficking
  • protein transduction domains

Published Papers

There is no accepted submissions to this special issue at this moment.
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