Special Issue "Screening for Biologically Active Compounds"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (31 January 2014)
Prof. Dr. Jonathan B. Baell
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville VIC 3052, Australia
High throughput screening (HTS) has come a long way since the first time in the late 1980s that it was implemented in a truly automated fashion. It has become a mainstay as a starting point for the discovery of new drugs, with a particular utility in discovering new chemistry for new biology. Recent technological advances in assay methodologies have been outstanding, in part facilitating access to HTS by increasingly large numbers of academic researchers. This has imparted to HTS an extra level of exploratory research, with a particular focus on chemical biology and tool compound discovery and development. In addition to target-based screening, phenotypic screening is gaining an increasing and in some areas dominating foothold. However, HTS is not an instant solution to drug discovery, because there is no such thing. Assay artefacts continue to be the bane of the hit discovery researcher. Some targets are shown to be undruggable. This special issue will focus on all these aspects of state-of-the-art high throughput screening.
Prof. Dr. Jonathan B. Baell
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- phenotypic screening
- target-based screening
- hit discovery
- hit-to-Lead optimization
- hit triage
- assay artefacts
Biology 2014, 3(1), 101-138; doi:10.3390/biology3010101
Received: 7 January 2014; in revised form: 22 January 2014 / Accepted: 22 January 2014 / Published: 10 February 2014| PDF Full-text (1360 KB) | HTML Full-text | XML Full-text
Article: Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail
Biology 2014, 3(1), 139-156; doi:10.3390/biology3010139
Received: 9 December 2013; in revised form: 23 January 2014 / Accepted: 26 January 2014 / Published: 13 February 2014| PDF Full-text (543 KB) | HTML Full-text | XML Full-text | Supplementary Files
Article: In Vitro High Throughput Screening, What Next? Lessons from the Screening for Aurora Kinase Inhibitors
Biology 2014, 3(1), 167-175; doi:10.3390/biology3010167
Received: 3 December 2013; in revised form: 13 February 2014 / Accepted: 14 February 2014 / Published: 27 February 2014| PDF Full-text (387 KB) | HTML Full-text | XML Full-text
Review: Screening for Antifibrotic Compounds Using High Throughput System Based on Fluorescence Polarization
Biology 2014, 3(2), 281-294; doi:10.3390/biology3020281
Received: 15 January 2014; in revised form: 28 February 2014 / Accepted: 1 April 2014 / Published: 10 April 2014| PDF Full-text (931 KB) | HTML Full-text | XML Full-text
Biology 2014, 3(2), 345-367; doi:10.3390/biology3020345
Received: 24 February 2014; in revised form: 16 May 2014 / Accepted: 22 May 2014 / Published: 30 May 2014| PDF Full-text (690 KB) | HTML Full-text | XML Full-text
Last update: 31 July 2014