Special Issue "Screening for Biologically Active Compounds"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (31 January 2014)
High throughput screening (HTS) has come a long way since the first time in the late 1980s that it was implemented in a truly automated fashion. It has become a mainstay as a starting point for the discovery of new drugs, with a particular utility in discovering new chemistry for new biology. Recent technological advances in assay methodologies have been outstanding, in part facilitating access to HTS by increasingly large numbers of academic researchers. This has imparted to HTS an extra level of exploratory research, with a particular focus on chemical biology and tool compound discovery and development. In addition to target-based screening, phenotypic screening is gaining an increasing and in some areas dominating foothold. However, HTS is not an instant solution to drug discovery, because there is no such thing. Assay artefacts continue to be the bane of the hit discovery researcher. Some targets are shown to be undruggable. This special issue will focus on all these aspects of state-of-the-art high throughput screening.
Prof. Dr. Jonathan B. Baell
Manuscript Submission Information
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- phenotypic screening
- target-based screening
- hit discovery
- hit-to-Lead optimization
- hit triage
- assay artefacts