Table of Contents
J. Fungi, Volume 3, Issue 3 (September 2017)
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Cover Story (view full-size image) The response of immune cells to fungal biofilms is not well understood. A 3D live cell imaging [...] Read more. The response of immune cells to fungal biofilms is not well understood. A 3D live cell imaging analysis of macrophage interactions with Candida albicans revealed impaired phagocyte migration towards cells forming biofilms compared to cells in suspension. Alterations in cell wall architecture enhanced macrophage migration towards planktonic fungal cells, but did not affect the response towards C. albicans biofilms. Therefore biofilms are not only recalcitrant to antifungal therapy, but they also limit the effectiveness of the innate immune response. View this paper