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J. Fungi 2017, 3(3), 46; doi:10.3390/jof3030046

Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds

1
National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland
2
Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland
*
Authors to whom correspondence should be addressed.
Received: 27 July 2017 / Revised: 16 August 2017 / Accepted: 22 August 2017 / Published: 26 August 2017
(This article belongs to the Special Issue Antifungal Peptides)
View Full-Text   |   Download PDF [1356 KB, uploaded 26 August 2017]   |  

Abstract

Invasive fungal infections are associated with high mortality rates, despite appropriate antifungal therapy. Limited therapeutic options, resistance development and the high mortality of invasive fungal infections brought about more concern triggering the search for new compounds capable of interfering with fungal viability and virulence. In this context, peptides gained attention as promising candidates for the antimycotics development. Variety of structural and functional characteristics identified for various natural antifungal peptides makes them excellent starting points for design novel drug candidates. Current review provides a brief overview of natural and synthetic antifungal peptides. View Full-Text
Keywords: antifungal peptides; fungal pathogens; Candida species antifungal peptides; fungal pathogens; Candida species
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Bondaryk, M.; Staniszewska, M.; Zielińska, P.; Urbańczyk-Lipkowska, Z. Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds. J. Fungi 2017, 3, 46.

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