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J. Fungi 2017, 3(3), 41; doi:10.3390/jof3030041

Strategies to Reduce Mortality in Adult and Neonatal Candidemia in Developing Countries

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India
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Received: 8 June 2017 / Revised: 13 July 2017 / Accepted: 16 July 2017 / Published: 19 July 2017
(This article belongs to the Special Issue Fungal Infections in the Developing World)
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Abstract

Candidemia, the commonest invasive fungal infection, is associated with high morbidity and mortality in developing countries, though the exact prevalence is not known due to lack of systematic epidemiological data from those countries. The limited studies report a very high incidence of candidemia and unique epidemiology with a different spectrum of Candida species. The recent global emergence of multi-drug resistant Candida auris is looming large as an important threat in hospitalized patients of developing countries. While managing candidemia cases in those countries several challenges are faced, which include poor infrastructure; compromised healthcare and infection control practices; misuse and overuse of antibiotics and steroids; lack of awareness in fungal infections; non-availability of advance diagnostic tests and antifungal drugs in many areas; poor compliance to antifungal therapy and stewardship program. Considering the above limitations, innovative strategies are required to reduce mortality due to candidemia in adults and neonates. In the present review, we have unraveled the challenges of candidemia faced by low resource countries and propose a ten part strategy to reduce mortality due candidemia. View Full-Text
Keywords: candidemia; developing countries; strategies; mortality candidemia; developing countries; strategies; mortality
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kaur, H.; Chakrabarti, A. Strategies to Reduce Mortality in Adult and Neonatal Candidemia in Developing Countries. J. Fungi 2017, 3, 41.

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