Table of Contents
Antioxidants, Volume 6, Issue 4 (December 2017)
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Cover Story (view full-size image) We investigated the use of MnTE-2-PyP, a mimic of superoxide dismutase (SOD), to prevent [...] Read more. We investigated the use of MnTE-2-PyP, a mimic of superoxide dismutase (SOD), to prevent radiation-induced fibrosis. In this study, we show that MnTE-2-PyP is a potent radio-protector of multiple cell types. Specifically, MnTE-2-PyP prevents acute transformation of fibroblasts to myofibroblasts, which causes fibrosis. The proposed mechanisms and changes in gene transcription after MnTE-2-PyP pre-treatment that lead to protection from radiation damage will be discussed in this paper. View this paper