Next Article in Journal
Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease
Previous Article in Journal
Trans-Plasma Membrane Electron Transport and Ascorbate Efflux by Skeletal Muscle
Previous Article in Special Issue
NADPH Oxidases, Angiogenesis, and Peripheral Artery Disease
Article Menu

Export Article

Open AccessReview
Antioxidants 2017, 6(4), 90; doi:10.3390/antiox6040090

Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate

1
Vascular Biology & Therapeutics, School of Biotechnology, Dublin City University, D09NR58 Dublin, Ireland
2
Department of Surgery (Research), University of Rochester Medical Centre, Rochester, NY 14620, USA
*
Author to whom correspondence should be addressed.
Received: 2 October 2017 / Revised: 21 October 2017 / Accepted: 7 November 2017 / Published: 14 November 2017
(This article belongs to the Special Issue ROS Derived from NADPH Oxidase (NOX) in Angiogenesis)
View Full-Text   |   Download PDF [2483 KB, uploaded 14 November 2017]   |  

Abstract

The generation of reactive oxygen species (ROS) and an imbalance of antioxidant defence mechanisms can result in oxidative stress. Several pro-atherogenic stimuli that promote intimal-medial thickening (IMT) and early arteriosclerotic disease progression share oxidative stress as a common regulatory pathway dictating vascular cell fate. The major source of ROS generated within the vascular system is the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes (Nox), of which seven members have been characterized. The Nox family are critical determinants of the redox state within the vessel wall that dictate, in part the pathophysiology of several vascular phenotypes. This review highlights the putative role of ROS in controlling vascular fate by promoting endothelial dysfunction, altering vascular smooth muscle phenotype and dictating resident vascular stem cell fate, all of which contribute to intimal medial thickening and vascular disease progression. View Full-Text
Keywords: Nox; ROS; vascular smooth muscle; endothelial; stem cells; adventitial cells; arteriosclerotic disease; intimal-medial thickening Nox; ROS; vascular smooth muscle; endothelial; stem cells; adventitial cells; arteriosclerotic disease; intimal-medial thickening
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Burtenshaw, D.; Hakimjavadi, R.; Redmond, E.M.; Cahill, P.A. Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate. Antioxidants 2017, 6, 90.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top