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Antioxidants 2017, 6(4), 104; doi:10.3390/antiox6040104

The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Lung Architecture Remodeling

1
Department of Pediatric, University of Illinois at Chicago, Chicago, IL 60612, USA
2
Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
3
Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA
*
Author to whom correspondence should be addressed.
Received: 13 November 2017 / Revised: 8 December 2017 / Accepted: 14 December 2017 / Published: 19 December 2017
(This article belongs to the Special Issue ROS Derived from NADPH Oxidase (NOX) in Angiogenesis)
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Abstract

Chronic lung disorders, such as pulmonary artery hypertension (PAH), chronic obstructive pulmonary disease (COPD), asthma and neonatal bronchopulmonary dysplasia (BPD), are characterized by airway and/or vascular remodeling. Despite differences in the pathology, reactive oxygen species (ROS) have been highlighted as a critical contributor to the initiation and development of airway and vascular remodeling. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) appear to play a pivotal role in lung signaling, leading to marked changes in pulmonary airway and vascular cell phenotypes, including proliferation, hypertrophy and apoptosis. In this review, we summarized the current literature regarding the role of Nox in the airway and vascular remodeling. View Full-Text
Keywords: NADPH oxidase; remodeling; PAH; COPD; asthma; BPD NADPH oxidase; remodeling; PAH; COPD; asthma; BPD
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Harijith, A.; Natarajan, V.; Fu, P. The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Lung Architecture Remodeling. Antioxidants 2017, 6, 104.

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