Special Issue "Viruses and the Ubiquitin/Proteasome System"
Deadline for manuscript submissions: 30 September 2013
Dr. Matthew D. Weitzman
Associate Director, Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 302B Abramson Research Center, 3615 Civic Center Blvd. Philadelphia, PA 19104-4318, USA
Phone: +267 425 2068
Interests: Virology; Virus Replication; DNA Damage and Repair; Genome Instability; Viral Vectors
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed Open Access monthly journal published by MDPI.
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: Role of Ubiquitin and Multivesicular Body Biogenesis System in Viral Egress from Infected Cells: How Viruses Exploit Fundamental Cellular Pathways
Authors: Arianna Calistri, Denis Munegato, Cristiano Salata, Cristina Parolin and Giorgio Palù
Affiliation: Department of Molecular Medicine, University of Padova, Italy
Abstract: Despite differences in replication strategies, viruses frequently use similar mechanisms to accomplish entry, viral replication and budding. Enveloped viruses acquire their envelope by budding through cellular membranes of different origin. A productive infection requires that all the components necessary for the formation of infectious particles localize to the membrane at the site where budding will take place. Several enveloped viruses, contain at the level of structural proteins amminoacidic motifs, known as late domains (L-domains), essential in the late steps of viral replication. The efforts to understand the mechanisms by which L-domains facilitate retroviral budding brought to the evidence that ubiquitin and ubiquitin ligases play a role in this essential step of viral replication. The link between the ubiquitination machinery and the viral egress from infected cells was not easy to explain till the discovery of the involvement of the endocytic pathway in retroviral budding. The eucaryotic endosomal system is a complex network of vesicles and organelles surrounded by membranes which coordinates protein transport from the plasma membrane to the trans-Golgi network (TGN) and/or to the lysosomes. A central role at this level is played by the multivesicular bodies (MVBs). Several proteins involved in the biogenesis of these organelles are clearly essential for enveloped viral budding and more importantly their function is regulated by ubiquitination. In this review, we will go through the major steps that brought ours and other research groups to the discovery of the involvement of MVB biogenesis pathway in retoviral budding and we will focus, in particular, on the role played by ubiquitin and ubiquitin ligsases in this context. We will also show how the ability of viruses to exploit MVB biogenesis components is not limited to retroviruses, but is a feature shared among most of the RNA and DNA enveloped viruses, thus appearing as one of the most amazing example of co-evolution between pathogen and host. Finally, we will discuss the most recent and challenging areas of research in this field, such as the function of lipids in viral budding.
Last update: 29 April 2013