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Viruses 2014, 6(11), 4683-4702; doi:10.3390/v6114683

Hepatitis B Virus HBx Protein Interactions with the Ubiquitin Proteasome System

1
Graduate Program in Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
2
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Received: 1 October 2014 / Revised: 16 November 2014 / Accepted: 20 November 2014 / Published: 24 November 2014
(This article belongs to the Special Issue Viruses and the Ubiquitin/Proteasome System)
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Abstract

The hepatitis B virus (HBV) causes acute and chronic hepatitis, and the latter is a major risk factor for the development of hepatocellular carcinoma (HCC). HBV encodes a 17-kDa regulatory protein, HBx, which is required for virus replication. Although the precise contribution(s) of HBx to virus replication is unknown, many viruses target cellular pathways to create an environment favorable for virus replication. The ubiquitin proteasome system (UPS) is a major conserved cellular pathway that controls several critical processes in the cell by regulating the levels of proteins involved in cell cycle, DNA repair, innate immunity, and other processes. We summarize here the interactions of HBx with components of the UPS, including the CUL4 adaptor DDB1, the cullin regulatory complex CSN, and the 26S proteasome. Understanding how these protein interactions benefit virus replication remains a challenge due to limited models in which to study HBV replication. However, studies from other viral systems that similarly target the UPS provide insight into possible strategies used by HBV. View Full-Text
Keywords: hepatitis B virus; HBx; ubiquitin; DDB1; CSN; proteasome hepatitis B virus; HBx; ubiquitin; DDB1; CSN; proteasome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Minor, M.M.; Slagle, B.L. Hepatitis B Virus HBx Protein Interactions with the Ubiquitin Proteasome System. Viruses 2014, 6, 4683-4702.

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