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Viruses 2013, 5(7), 1787-1801; doi:10.3390/v5071787
Review

Posttranslational Modifications of HIV-1 Integrase by Various Cellular Proteins during Viral Replication

 and *
Received: 17 May 2013; in revised form: 8 July 2013 / Accepted: 9 July 2013 / Published: 16 July 2013
(This article belongs to the Special Issue Viruses and the Ubiquitin/Proteasome System)
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Abstract: HIV-1 integrase (IN) is a key viral enzyme during HIV-1 replication that catalyzes the insertion of viral DNA into the host genome. Recent studies have provided important insights into the multiple posttranslational modifications (PTMs) of IN (e.g., ubiquitination, SUMOylation, acetylation and phosphorylation), which regulate its multifaceted functions. A number of host cellular proteins, including Lens Epithelium‑derived Growth factor (LEDGF/p75), p300 and Ku70 have been shown to interact with IN and be involved in the PTM process of IN, either facilitating or counteracting the IN PTMs. Although previous studies have revealed much about the important roles of IN PTMs, how IN functions are fine-tuned by these PTMs under the physiological setting still needs to be determined. Here, we review the advances in the understanding of the mechanisms and roles of multiple IN PTMs.
Keywords: HIV; integrase; posttranslational modification; ubiquitination; SUMOylation; acetylation; phosphorylation HIV; integrase; posttranslational modification; ubiquitination; SUMOylation; acetylation; phosphorylation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zheng, Y.; Yao, X. Posttranslational Modifications of HIV-1 Integrase by Various Cellular Proteins during Viral Replication. Viruses 2013, 5, 1787-1801.

AMA Style

Zheng Y, Yao X. Posttranslational Modifications of HIV-1 Integrase by Various Cellular Proteins during Viral Replication. Viruses. 2013; 5(7):1787-1801.

Chicago/Turabian Style

Zheng, Yingfeng; Yao, Xiaojian. 2013. "Posttranslational Modifications of HIV-1 Integrase by Various Cellular Proteins during Viral Replication." Viruses 5, no. 7: 1787-1801.


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