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Viruses 2010, 2(10), 2356-2380; doi:10.3390/v2102356
Review

Poxvirus Exploitation of the Ubiquitin-Proteasome System

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Received: 2 September 2010; in revised form: 27 September 2010 / Accepted: 30 September 2010 / Published: 19 October 2010
(This article belongs to the Special Issue Viruses and the Ubiquitin/Proteasome System)
Download PDF [549 KB, uploaded 19 October 2010]
Abstract: Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome system, including members of the Poxviridae family. Members of the poxvirus family have recently been shown to encode BTB/kelch and ankyrin/F-box proteins that interact with cullin-3 and cullin-1 based ubiquitin ligases, respectively. Multiple members of the poxvirus family also encode ubiquitin ligases with intrinsic activity. This review describes the numerous mechanisms that poxviruses employ to manipulate the ubiquitin-proteasome system.
Keywords: poxvirus; ubiquitin; F-box; BTB/kelch; RING finge poxvirus; ubiquitin; F-box; BTB/kelch; RING finge
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Barry, M.; Van Buuren, N.; Burles, K.; Mottet, K.; Wang, Q.; Teale, A. Poxvirus Exploitation of the Ubiquitin-Proteasome System. Viruses 2010, 2, 2356-2380.

AMA Style

Barry M, Van Buuren N, Burles K, Mottet K, Wang Q, Teale A. Poxvirus Exploitation of the Ubiquitin-Proteasome System. Viruses. 2010; 2(10):2356-2380.

Chicago/Turabian Style

Barry, Michele; Van Buuren, Nicholas; Burles, Kristin; Mottet, Kelly; Wang, Qian; Teale, Alastair. 2010. "Poxvirus Exploitation of the Ubiquitin-Proteasome System." Viruses 2, no. 10: 2356-2380.


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