Special Issue "Toxin-Antibody Interactions"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (31 January 2014)
Dr. Nicholas J. Mantis
Division of Infectious Disease, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
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Phone: +1 518 473 7487
Fax: +1 518 402 4773
Interests: plant and bacterial protein toxins; neutralizing antibodies; vaccines; mucosal tissues; animal models; small molecule inhibitors
Antibodies are remarkable in their ability to inactivate even the most potent plant and microbial toxins, including botulinum, tetanus, diphtheria, anthrax and ricin toxins. While this fact has been recognized for more than a century, surprisingly little is known about the molecular mechanisms by which antibodies actually neutralize toxins. Indeed, historically, there has been little incentive to investigate the nature of toxin-antibody interactions because of the success of so many toxin vaccines and therapies. However, this has changed in the past decade with the global demand in the public health and biodefense sectors for new generation antibody-based countermeasures that are safer and more effective. With the surge in new research, it is now becoming increasingly apparent that the interactions between toxins-antibodies are as complex, sophisticated and interesting as the toxins themselves.
The goal of this special issue of Toxins is to provide a state-of-the-art look into the diverse mechanisms by which antibodies neutralize toxins and insights into how understanding these interactions will have applications for next generation vaccines and therapeutics.
Dr. Nicholas J. Mantis
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.