Next Article in Journal
Microcystins Alter Chemotactic Behavior in Caenorhabditis elegans by Selectively Targeting the AWA Sensory Neuron
Previous Article in Journal
Further Insights into Brevetoxin Metabolism by de Novo Radiolabeling
Previous Article in Special Issue
Role of Fc in Antibody-Mediated Protection from Ricin Toxin
Article Menu

Export Article

Open AccessReview
Toxins 2014, 6(6), 1799-1812; doi:10.3390/toxins6061799

Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli

1
Division of Infectious Diseases, Washington University School of Medicine, 660 South Euclid Avenue; Saint Louis, MO 63110, USA
2
Molecular Microbiology and Microbiobial Pathogenesis Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, Campus Box 8051, 660 South Euclid Avenue; Saint Louis, MO 63110, USA
3
Veterans Affairs Medical Center, Saint Louis, MO 63106, USA
*
Author to whom correspondence should be addressed.
Received: 7 March 2014 / Revised: 23 April 2014 / Accepted: 15 May 2014 / Published: 10 June 2014
(This article belongs to the Special Issue Toxin-Antibody Interactions)
View Full-Text   |   Download PDF [285 KB, uploaded 10 June 2014]

Abstract

Enterotoxigenic Escherichia coli (ETEC) are a leading cause of diarrheal illness in developing countries. Despite the discovery of these pathogens as a cause of cholera-like diarrhea over 40 years ago, and decades of vaccine development effort, there remains no broadly protective ETEC vaccine. The discovery of new virulence proteins and an improved appreciation of the complexity of the molecular events required for effective toxin delivery may provide additional avenues to pursue in development of an effective vaccine to prevent severe diarrhea caused by these important pathogens. View Full-Text
Keywords: enterotoxin; diarrhea; neutralizing antibodies; heat-labile enterotoxin; heat-stable enterotoxin; enterotoxigenic Escherichia coli; vaccines; subunit; vaccines; live-attenuated enterotoxin; diarrhea; neutralizing antibodies; heat-labile enterotoxin; heat-stable enterotoxin; enterotoxigenic Escherichia coli; vaccines; subunit; vaccines; live-attenuated
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fleckenstein, J.M.; Sheikh, A. Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli. Toxins 2014, 6, 1799-1812.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top