Special Issue "Feature Papers"


A special issue of Toxics (ISSN 2305-6304).

Deadline for manuscript submissions: closed (15 October 2013)

Special Issue Editor

Guest Editor
Prof. Dr. David Bellinger
Boston Children's Hospital, Harvard Medical School, Harvard University, 300 Longwood Ave, Boston, MA 02115, USA
Website: http://www.childrenshospital.org/cfapps/research/data_admin/Site156/mainpageS156P0.html
Phone: 617 355 6565
Fax: +1 617 730 0618
Interests: children; epidemiology; metals; brain

Special Issue Information

Dear Colleagues,

With this inaugural issue, Toxics begins its life as a peer-reviewed, open access journal focusing on all aspects of toxic chemicals. We are interested in publishing papers that present a wide range of perspectives on toxicants and naturally occurring toxins, including exposure, biomarkers, kinetics, biological effects, fate and transport, treatment, and remediation. Toxics differs from many other journals in the absence of a page or word limit on contributions, permitting authors to present their work in as much detail as they wish. Toxics will publish original research papers, conventional reviews, meta-analyses, short communications, theoretical papers, case reports, commentaries and policy perspectives, and book reviews (Book reviews will be solicited and should not be submitted without invitation). Toxins and toxicants concern individuals from a wide range of disciplines, and Toxics is interested in receiving papers that represent the full range of approaches applied to their study, including in vitro studies, studies that use experimental animal or non-animal models, studies of humans or other biological populations, and mathematical modeling. We are excited to get underway and look forward to working with authors in the scientific and medical communities and providing them with a novel venue for sharing their work.

Dr. David Bellinger


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • toxicants, toxins
  • exposure
  • biomarkers
  • kinetics
  • biological effects
  • fate and transport
  • treatment
  • remediation

Published Papers (5 papers)

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Displaying article 1-5
p. 17-34
by ,  and
Toxics 2014, 2(1), 17-34; doi:10.3390/toxics2010017
Received: 18 November 2013 / Revised: 6 January 2014 / Accepted: 10 January 2014 / Published: 22 January 2014
Show/Hide Abstract | Cited by 1 | PDF Full-text (616 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Feature Papers)
abstract graphic
p. 46-59
by , , , , ,  and Sr.
Toxics 2013, 1(1), 46-59; doi:10.3390/toxics1010046
Received: 16 October 2013 / Revised: 6 November 2013 / Accepted: 14 November 2013 / Published: 25 November 2013
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(This article belongs to the Special Issue Feature Papers)
p. 36-45
by , , , , , , ,  and
Toxics 2013, 1(1), 36-45; doi:10.3390/toxics1010036
Received: 3 October 2013 / Revised: 6 November 2013 / Accepted: 7 November 2013 / Published: 19 November 2013
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(This article belongs to the Special Issue Feature Papers)
p. 18-35
by  and
Toxics 2013, 1(1), 18-35; doi:10.3390/toxics1010018
Received: 27 September 2013 / Revised: 6 November 2013 / Accepted: 7 November 2013 / Published: 18 November 2013
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(This article belongs to the Special Issue Feature Papers)
p. 2-17
Toxics 2013, 1(1), 2-17; doi:10.3390/toxics1010002
Received: 19 August 2013 / Revised: 9 September 2013 / Accepted: 24 September 2013 / Published: 15 October 2013
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Article
Title: Investigating the occurrence of polybrominated diphenyl ether (PBDE) flame retardants in arctic snow: long-range transport vs. local sources
Authors: Lorenza Misuri, Garry Codling, Crispin Halsall, Alessandra Cincinelli and Roland Kallenborn
Affiliation: Department of Chemistry, University of Florence, Via della Lastruccia, 3–50019 Sesto Fiorentino, Italy;
E-Mail: c.halsall@lancaster.ac.uk
Abstract: PBDEs were measured in the seasonal snowpack and overlying air in Adventdalen near the town of Longyearbyen, Svalbard in the Norwegian Arctic. The aim of the study was to assess the impact of the town and associated mining activities on the levels of flame retardants in both air and snow. PBDE levels in air were dominated by the lower brominated congeners, BDE-47 and -99 with concentrations averaging 4.04 and 6.02 pg/m3, respectively. The higher brominated congeners were present in greater abundance in the snow with significant particle-bound fractions. Many of the snow samples contained significant coal-dust type particle matter. The concentrations observed in this study were similar to levels observed in more remote locations within the Arctic and suggest that local sources are having a negligible impact on the local environment.
Keywords: persistent organic pollutants; environmental fate; cryosphere

Title: Chronic Exposure to Particulate Nickel Induces Neoplastic Transformation in Human Lung Epithelial Cells
Authors: Amie L. Holmes, Therry The, and John Pierce Wise, Sr.
Affiliation: Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, 96 Falmouth St., Portland, ME. 04103; E-Mail: john.wise.sr@gmail.com
Abstract: Nickel is a well-known human lung carcinogen with the particulate form being the most potent; however, the carcinogenic mechanism remains largely unknown. One hypothesis for the increased carcinogenicity of particulate nickel is the differences in exposure times with the particulates leading to more chronic exposures, while the soluble nickel is more rapidly cleared from the lungs. Thus, the goal of this study was to investigate the effects of longer exposures to particulate nickel in order to better mimic the exposure to particulate nickel in humans. We found that nickel sulfide induced concentration- and time-dependent increases in both cytotoxicity and genotoxicity in human lung epithelial cells (BEP2D). Chronic exposure to nickel sulfide readily induced cellular transformation, inducing 26, 29 and 24 foci/10 dishes after exposure to 1, 2.5 and 5 ug/cm2 nickel sulfide, respectively. Sixty, 90 and 70% of the foci isolated from 1, 2.5, and 5 ug/cm2 nickel sulfide treatments formed colonies in soft agar and these foci had an average of 11, 17 and 29 colonies per dish, respectively. Thus, chronic exposure to particulate nickel induces genotoxicity and cellular transformation in human lung epithelial cells. This work is funded by grant W911NF-09-1-0296 (J.P.W) and Maine Center for Toxicology and Environmental Health.

Title: Ecotoxicology: the challenges for the XXI Century
Authors: Marco Vighi1,* and Sara Villa1
Affiliation: 1 University of Milano Bicocca – Department of Earth and Environmental Sciences (DISAT), Piazza dellaScienza, 1 – 20126 Milano, Italy; E-Mail: sara.villa@unimib.it
*Author to whom correspondence should be addressed; E-Mail: marco.vighi@unimib.it;
Abstract: Usual procedures for ecological risk assessment have been based for decades on simplified approaches in order to provide basic information on the huge amount of chemicals introduced into the environment. These approaches allowed the development of international regulatory tools capable to substantially reduce adverse effects for ecosystems in developed countries. Nevertheless, these approaches suffer for a lack of ecological realism and are poorly suitable for understanding the actual consequences on ecosystem health. The need for more ecologically-based approaches is now recognized by the scientific community and has been highlighted by a recent document of the European Commission. In this paper a synthesis is presented of the most important issues and the needs for research for improving the ecological realism of exposure and effect assessment and the tools that should be developed for reaching this objective.
Keywords: ecotoxicology; ecological risk assessment; exposure assessment; effect assessment; ecological modeling; European Commission

Last update: 23 September 2013

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