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Toxics 2014, 2(1), 17-34; doi:10.3390/toxics2010017
Review

Chemical Atherogenesis: Role of Endogenous and Exogenous Poisons in Disease Development

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Received: 18 November 2013; in revised form: 6 January 2014 / Accepted: 10 January 2014 / Published: 22 January 2014
(This article belongs to the Special Issue Feature Papers)
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Abstract: Chemical atherogenesis is an emerging field that describes how environmental pollutants and endogenous toxins perturb critical pathways that regulate lipid metabolism and inflammation, thus injuring cells found within the vessel wall. Despite growing awareness of the role of environmental pollutants in the development of cardiovascular disease, the field of chemical atherogenesis can broadly include both exogenous and endogenous poisons and the study of molecular, biochemical, and cellular pathways that become dysregulated during atherosclerosis. This integrated approach is logical because exogenous and endogenous toxins often share the same mechanism of toxicity. Chemical atherogenesis is a truly integrative discipline because it incorporates concepts from several different fields, including biochemistry, chemical biology, pharmacology, and toxicology. This review will provide an overview of this emerging research area, focusing on cellular and animal models of disease.
Keywords: chemical atherogenesis; endogenous toxins; environmental pollutants; atherosclerosis; carboxylesterases; inflammation; oxidative stress chemical atherogenesis; endogenous toxins; environmental pollutants; atherosclerosis; carboxylesterases; inflammation; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ross, M.K.; Matthews, A.T.; Mangum, L.C. Chemical Atherogenesis: Role of Endogenous and Exogenous Poisons in Disease Development. Toxics 2014, 2, 17-34.

AMA Style

Ross MK, Matthews AT, Mangum LC. Chemical Atherogenesis: Role of Endogenous and Exogenous Poisons in Disease Development. Toxics. 2014; 2(1):17-34.

Chicago/Turabian Style

Ross, Matthew K.; Matthews, Anberitha T.; Mangum, Lee C. 2014. "Chemical Atherogenesis: Role of Endogenous and Exogenous Poisons in Disease Development." Toxics 2, no. 1: 17-34.

Toxics EISSN 2305-6304 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert