Special Issue "Miniaturized Wireless Biosensors"


A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 31 August 2014

Special Issue Editor

Guest Editor
Dr Benoit Gosselin
Department of Electrical and Computer Engineering, Université Laval, Québec (Québec) G1V 0A6, Canada
E-Mail: Benoit.Gosselin@gel.ulaval.ca
Phone: +1 418 656-2131 ext. 3555
Fax: +1 418 656-3159
Interests: VLSI circuits for bioinstrumentation; wireless biosensors; implantable electronics; brain computer interfaces; and low-power analog/mixed-mode integrated circuits

Special Issue Information

Dear Colleagues,

The advancement in wireless technology and micro/nano-fabrication techniques have created a tremendous opportunity for using miniaturized wireless microelectronic devices in novel point-of-care diagnostic and prosthetic systems for a variety of health and life science applications. These new devices take advantage of miniaturized sensor technology to interface directly with complex biological structures like tissues, cells and molecules. For example, micro-electro-mechanical systems, such as microelectrode arrays and microfluidic channels, allow the study of neurons and manipulation of blood cells, while microlenses are used in low-cost fluorescence imagers. Other emerging devices, like brain machine interfaces, are opening up new opportunities to gain a better understanding of the root causes of several neuronal disorders, like the Parkinson’s disease, by extracting important biological parameters in freely moving animals. Such microsystems typically combine one or several application-specific integrated circuits with various sensor technologies into lightweight and self-contained formats that can easily be worn or implanted in the body to offer a very high level of functionality. The key requirements from such systems are: the extraction, the analysis, and the transmission of biological data in real time with excellent signal quality through a wireless connection. They are typically powered by a small battery, or by an inductive link, the power transmitter for which is external to the body, requiring extremely low power consumption to maximize the operational life expectancy.

Dr. Benoit Gosselin
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

Published Papers

No papers have been published in this special issue yet, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Article
Title: An Arch-shaped Intraoral Tongue Drive System with A Built-In System-on-a-Chip Tongue-Computer Interface
Authors: Hangue Park and Maysam Ghovanloo
Affiliations: GT-Bionics Lab, School of Electrical and Computer Engineering, Georgia Institute of Technology, 85 5th St. NW, Atlanta, GA 30308, USA; E-Mail: mgh@gatech.edu Abstract:
We present a new arch-shaped intraoral Tongue Drive System (iTDS-A) designed to be mounted on the buccal shelf in the user's mouth. The iTDS-A system-on-a-chip (SoC) amplifies and digitizes the raw magnetic sensor data from four 3-axis magnetoresistive bridge sensors, and sends it wirelessly to an external TDS universal interface (UI) via an inductive coil or a meander antenna. A built-in transmitter (Tx) employs a dual-band radio that can operate at either 27 or 432 MHz bands, whichever offers a more robust connection, with the help of a built-in super-regenerative receiver (SR-Rx) fand the TDS-UI. An accompanying FPGA generates data packets for the built-in Tx. The iTDS-A SoC was implemented in a 0.35-µm 2P3M Std. CMOS process and on average consumes 2.8 mW and 3.3 mW at 27 MHz and 432 MHz, respectively.

Type of Paper: Article
Novel Wireless-Communicating Textile Devices Made from Multi-Material and Minimally-Invasive Fibers.
Authors: Stephan Gorgutsa 1, Victor Bélanger-Garnier 1, Bora Ung 1, Jeff Viens 1, Benoit Gosselin 2, Sophie LaRochelle 1,2 and Younès Messaddeq 1,3
1 Center for Optics Photonics and Lasers (COPL), Laval University, Quebec, QC, Canada
Dépt. génie électrique et génie informatique, Laval University, Quebec, QC, Canada
Dépt. physique, génie physique et optique, Laval University, Quebec, QC, Canada
The ability to integrate multiple materials into miniaturized fiber structures enables the realization of novel textile devices with higher-level functionalities and minimally-invasive attributes.  In this work, we present novel textile fabrics integrating unobtrusive multi-material fibers that communicate through 2.4 GHz wireless networks with excellent signal quality.  The conductor elements of the textiles are embedded within the fibers themselves, providing electrical and chemical shielding against the environment, while preserving the mechanical and cosmetic properties of the garments.  These multi-material fibers combine insulating and conducting materials into a well-defined geometry, and represent a cost-effective and minimally-invasive approach to sensor fabrics and bio-sensing textiles connected in real time to mobile communications infrastructures, suitable for a variety of health and life science applications.

Type of Paper: Article
A Wireless Optogenetic Stimulator Headstage with Multichannel Neural Recording Capability
Reza Ameli 1, Abdollah Mirbozorgi 1, Alireza Avakh 1, Jean-Luc Neron 2, Yoan LeChasseur 2, Paul Brule Bareil 2, and Benoit Gosselin 1
1 Dept. of Electrical and Computer Eng., Université Laval, Quebec, QC G1V 0A6, Canada; E-Mail:Benoit.Gosselin@gel.ulaval.c
2 Doric Lenses Inc., Quebec, QC G1P 4N7, Canada
We present a miniature optogenetic headstage for wirelessly stimulating the brain of transgenic rodents using 2 high-power stimulating LEDs and two electrophysiological recording channels. The headstage is powered with a small Lithium-ion battery and is built using low-cost commercial off-the-shelf components. Light stimulation uses customizable stimulation patterns that allow tuning light waveform intensity, frequency and duty cycle easily. The optical power that is sourced from the LEDs is delivered to target light-sensitized neurons using implantable optical fibers. Each LED can drain up to 150 mA, which results in an optical power density delivered to target neurons of 200 mW/mm2. The miniature design of this headstage, using rigid-flex PCBs, results into a lightweight and compact device that is suitable to conduct long-term experiments with freely moving models.

Type of Paper: Review
Title: Wireless Bio-sensors for Point-of-Care Diagnostic Applications
Authors: Ebrahim Ghafar-Zadeh et al.
Affiliation: Electrical Engineering and Computer Science, York University, Canada; E-Mail: egz@cse.yorku.ca
Abstract: Recent advances of integrated bio-sensors have received significant interests from both industry and academia. Wireless bio-sensors offer the great advantages of continuous monitoring of biologically relevant conditions (e.g. Temperature and pH), metabolites and bio-molecules associated with various diseases such as Diabetes, brain cancer, Ischemia, and Alzheimer. In this review paper, we examine two major groups of miniaturized wireless bio-sensors - Implantable and wearable ones. Despite great progresses that have been made to develop wireless bio-sensors, the early detection of many diseases, remains to be a grand challenge from both technological and medical aspects. This paper addresses such challenges and introduces the state of art technology in this interdisciplinary approach.

Type: Article
Title: Wireless and Simultaneous Detections of Multiple Bio-Elements in a Single Sensor using Love Wave Biosensor
Author: Keekeun Lee, Professor, Ajou University, Korea
Abstract: A Love wave-based biosensor with a 440 MHz center frequency was developed for simultaneous detection of two different analytes of COMP and rabbit immunoglobulin G (hIgG) in a single sensor. The developed sensor consists of one-port surface acoustic wave (SAW) reflective delay lines, a poly(methyl methacrylate) (PMMA) waveguide layer, and two sensitive films. The Love wave biosensor was wirelessly characterized by using two antennas and a network analyzer. Binding of the analytes to the sensitive layers induced a large change in the time positions of the original reflection peaks, mainly due to the mass loading effect. The assessed time shifts in reflection peaks were matched well with the predicted values from coupling of mode (COM) modeling. The sensitivities evaluated from the sensitive films were 22.84 deg/mg/ml for hIgG and 2.74 deg/mg/ml for COMP.

Last update: 27 June 2014

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