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Sensors 2015, 15(9), 22776-22797; doi:10.3390/s150922776

A Wireless Optogenetic Headstage with Multichannel Electrophysiological Recording Capability

1
Department of Electrical and Computer Engineering, Université Laval, Quebec, QC G1V 0A6, Canada
2
Doric Lenses Inc., Quebec, QC G1P 4N7, Canada
3
Institut Universitaire en Santé Mentale de Québec, Quebec, QC G1J 2G3, Canada
4
Centre d'Optique, Photonique et Laser (COPL), Université Laval, Quebec, QC G1V 0A6, Canada
5
Department of Psychiatry & Neuroscience, Université Laval, Quebec, QC G1V 0A6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander Star
Received: 15 July 2015 / Revised: 26 August 2015 / Accepted: 29 August 2015 / Published: 9 September 2015
(This article belongs to the Special Issue Miniaturized Wireless Biosensors)
View Full-Text   |   Download PDF [4390 KB, uploaded 9 September 2015]   |  

Abstract

We present a small and lightweight fully wireless optogenetic headstage capable of optical neural stimulation and electrophysiological recording. The headstage is suitable for conducting experiments with small transgenic rodents, and features two implantable fiber-coupled light-emitting diode (LED) and two electrophysiological recording channels. This system is powered by a small lithium-ion battery and is entirely built using low-cost commercial off-the-shelf components for better flexibility, reduced development time and lower cost. Light stimulation uses customizable stimulation patterns of varying frequency and duty cycle. The optical power that is sourced from the LED is delivered to target light-sensitive neurons using implantable optical fibers, which provide a measured optical power density of 70 mW/mm2 at the tip. The headstage is using a novel foldable rigid-flex printed circuit board design, which results into a lightweight and compact device. Recording experiments performed in the cerebral cortex of transgenic ChR2 mice under anesthetized conditions show that the proposed headstage can trigger neuronal activity using optical stimulation, while recording microvolt amplitude electrophysiological signals. View Full-Text
Keywords: neural headstage; optogenetics; neural recording; optical stimulation; wireless sensor; brain-computer interfaces; low-power biotelemetry; electrophysiology neural headstage; optogenetics; neural recording; optical stimulation; wireless sensor; brain-computer interfaces; low-power biotelemetry; electrophysiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gagnon-Turcotte, G.; Kisomi, A.A.; Ameli, R.; Camaro, C.-O.D.; LeChasseur, Y.; Néron, J.-L.; Bareil, P.B.; Fortier, P.; Bories, C.; de Koninck, Y.; Gosselin, B. A Wireless Optogenetic Headstage with Multichannel Electrophysiological Recording Capability. Sensors 2015, 15, 22776-22797.

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