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Sensors 2014, 14(11), 21660-21675; doi:10.3390/s141121660

Wireless and Simultaneous Detections of Multiple Bio-Molecules in a Single Sensor Using Love Wave Biosensor

1
Korea Electronics Technology Institute, Seongnam-si, Gyeonggi-do 463-816, Korea
2
Department of Electronics Engineering, Ajou University, Suwon, Gyeonggi-do 443-749, Korea
*
Author to whom correspondence should be addressed.
Received: 27 August 2014 / Revised: 15 October 2014 / Accepted: 24 October 2014 / Published: 17 November 2014
(This article belongs to the Special Issue Miniaturized Wireless Biosensors)
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Abstract

A Love wave-based biosensor with a 440 MHz center frequency was developed for the simultaneous detection of two different analytes of Cartilage Oligomeric Matrix Protein (COMP) and rabbit immunoglobulin G (IgG) in a single sensor. The developed biosensor consists of one-port surface acoustic wave (SAW) reflective delay lines on a 41° YX LiNbO3 piezoelectric substrate, a poly(methyl methacrylate) (PMMA) waveguide layer, and two different sensitive films. The Love wave biosensor was wirelessly characterized using two antennas and a network analyzer. The binding of the analytes to the sensitive layers induced a large change in the time positions of the original reflection peaks mainly due to the mass loading effect. The assessed time shifts in the reflection peaks were matched well with the predicted values from coupling of mode (COM) modeling. The sensitivities evaluated from the sensitive films were ~15 deg/µg/mL for the rabbit IgG and ~1.8 deg/ng/mL for COMP. View Full-Text
Keywords: SAW; love wave; biosensor; wireless; batteryfree; IgG; COMP; antenna SAW; love wave; biosensor; wireless; batteryfree; IgG; COMP; antenna
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Oh, H.; Fu, C.; Kim, K.; Lee, K. Wireless and Simultaneous Detections of Multiple Bio-Molecules in a Single Sensor Using Love Wave Biosensor. Sensors 2014, 14, 21660-21675.

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