Special Issue "Microencapsulation Technology Applied to Pharmaceutics"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (31 August 2011)
Prof. Dr. Denis Poncelet
ENITIAA, rue de la géraudière, BP 82225, 44322 Nantes, France
Phone: +33 2 51 78 54 25
Interests: bioencapsulation; solid dispersion
Prof. Dr. Thierry Vandamme
Laboratory for the Conception and Application of Bioactive Molecules, UMR 7199 CNRS, Faculty of Pharmacy, University of Strasbourg, France
Interests: the design and the formulation of drugs by using microencapsulation technologies; in vitro / in vivo drug release and mathematical modeling; controlled release of drugs from different raw materials allowing sustained release or targeting; application for different administration routes
Microencapsulation is one of the techniques able to overcome the drug stability problem, and moreover, the possibility of formulating encapsulated drug delivery systems with controlled release rates. On these bases, microencapsulated dosage forms represent effective new therapeutic platforms. The active molecules are protected as long as they reach their specific action site. Most of the applied techniques of micro-encapsulation are based on modifications of the three basic methods: spray-drying, phase separation (coacervation), and solvent extraction/evaporation.
This special issue will cover the different interests of microencapsulation as a means to control or modify the release of drug substances from drug delivery systems. Since clinical efficacies have been reported to be improved by the encapsulation of pharmaceuticals, the bioavailability of drugs, control drug release kinetics, minimizing drug side effects, and taste masking of the bitter taste of drug substances will be discussed.
Prof. Dr. Thierry F. Vandamme
Prof. Dr. Denis Poncelet
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- encapsulation efficiency
- lipid formulation
- water-in-oil emulsion
- emulsion solvent evaporation
- membrane emulsification
- size controlled emulsion
- drug; targeting
- polymeric drug delivery systems
- taste masking
- self microemulsifying
Article: Effect of Microencapsulation Shear Stress on the Structural Integrity and Biological Activity of a Model Monoclonal Antibody, Trastuzumab
Pharmaceutics 2011, 3(3), 510-524; doi:10.3390/pharmaceutics3030510
Received: 4 July 2011; in revised form: 16 August 2011 / Accepted: 19 August 2011 / Published: 24 August 2011| Download PDF Full-text (402 KB) | Download XML Full-text
Review: The Application of Microencapsulation Techniques in the Treatment of Endodontic and Periodontal Diseases
Pharmaceutics 2011, 3(3), 538-571; doi:10.3390/pharmaceutics3030538
Received: 5 July 2011; in revised form: 9 August 2011 / Accepted: 24 August 2011 / Published: 26 August 2011| Download PDF Full-text (451 KB) | Download XML Full-text
Article: Development of Re-Usable Yeast-Gellan Gum Micro-Bioreactors for Potential Application in Continuous Fermentation to Produce Bio-Ethanol
Pharmaceutics 2011, 3(4), 731-744; doi:10.3390/pharmaceutics3040731
Received: 14 June 2011; in revised form: 29 September 2011 / Accepted: 11 October 2011 / Published: 17 October 2011| Download PDF Full-text (884 KB) | Download XML Full-text
Pharmaceutics 2011, 3(4), 793-829; doi:10.3390/pharmaceutics3040793
Received: 30 August 2011; in revised form: 18 October 2011 / Accepted: 27 October 2011 / Published: 4 November 2011| Download PDF Full-text (3281 KB) | Download XML Full-text
Article: Formulation Optimization of Sustained-Release Ammonio Methacrylate Copolymer Microspheres. Effects of Log P and Concentration of Polar Cosolvents, and Role of the Drug/Copolymer Ratio
Pharmaceutics 2011, 3(4), 830-847; doi:10.3390/pharmaceutics3040830
Received: 29 June 2011; in revised form: 11 October 2011 / Accepted: 27 October 2011 / Published: 10 November 2011| Download PDF Full-text (1004 KB) | Download XML Full-text
Pharmaceutics 2012, 4(1), 1-25; doi:10.3390/pharmaceutics4010001
Received: 9 December 2011; in revised form: 20 December 2011 / Accepted: 4 January 2012 / Published: 6 January 2012| Download PDF Full-text (7687 KB) | Download XML Full-text
Review: Novel Experimental and Clinical Therapeutic Uses of Low-Molecular-Weight Heparin/Protamine Microparticles
Pharmaceutics 2012, 4(1), 42-57; doi:10.3390/pharmaceutics4010042
Received: 1 December 2011; in revised form: 31 December 2011 / Accepted: 31 December 2011 / Published: 11 January 2012| Download PDF Full-text (759 KB) | Download XML Full-text
Pharmaceutics 2012, 4(1), 149-163; doi:10.3390/pharmaceutics4010149
Received: 21 December 2011; in revised form: 20 January 2012 / Accepted: 31 January 2012 / Published: 6 February 2012| Download PDF Full-text (239 KB) | Download XML Full-text
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Bioactive Food Compounds as Epigenetic Modulators in Prostate Cancer Prevention
Author: Clarissa Gerhauser, Joseph Huang and Christoph Plass
Affiliation: German Cancer Research Center, Epigenomics and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;
E-Mail: email@example.com (C.G.)
Abstract: Prostate cancer (PCa) is the most commonly diagnosed malignancy in men in industrialized countries, and the second leading cause of male cancer-related death. Epigenetic mechanisms, including changes in DNA methylation, chromatin modifications and noncoding RNAs, contribute to PCa development. Given the fact that epigenetic modifications occur early in carcinogenesis and represent potentially initiating events, they have been identified as promising new targets for cancer therapy and prevention. Micronutrients and naturally derived food substances currently under investigation for PCa prevention include green tea; soy and phytoestrogens; lycopene and tomato products; Allium and cruciferous vegetables, selenium, vitamins A, C, D, E, and various combinations thereof. The planned review will summarize their impact on DNA methylation of candidate genes (GSTP1, RARb2, p16, RASSF1A, hTERT), histone modifying enzymes (histone deacetylases, histone acetyl transferases, histone methyltransferases) and consequences on cell cycle, apoptosis and hormone signalling, miRNAs and their target genes, as well as results of in vivo studies in the transgenic TRAMP model, and prostate cancer xenograft studies.
Last update: 17 March 2011