Pharmaceutics 2011, 3(4), 731-744; doi:10.3390/pharmaceutics3040731
Article

Development of Re-Usable Yeast-Gellan Gum Micro-Bioreactors for Potential Application in Continuous Fermentation to Produce Bio-Ethanol

Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, S117543, Singapore
* Author to whom correspondence should be addressed.
Received: 14 June 2011; in revised form: 29 September 2011 / Accepted: 11 October 2011 / Published: 17 October 2011
(This article belongs to the Special Issue Microencapsulation Technology Applied to Pharmaceutics)
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Abstract: The objectives of this study were to investigate the feasibility of encapsulating yeast cells using gellan gum by an emulsification method and to evaluate the fermentation efficiency and the reusability of the micro-bioreactors produced. It was found that yeast cells could be successfully encapsulated to form relatively spherical micro-bioreactors with high specific surface area for mass transfer. Cell viability was found to be reduced by one log reduction after the emulsification process. The ethanol yield of the micro-bioreactors was comparable to that of free yeast in the first fermentation cycle. The micro-bioreactors remained intact and could be re-used up to 10 cycles of fermentation. Despite cell breakthrough, relatively high ethanol yields were obtained, indicating that the micro-bioreactors also functioned as regenerative reservoirs of yeast.
Keywords: microencapsulation; water-in-oil emulsion; gellan gum; micro-bioreactors; bioethanol

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MDPI and ACS Style

Tan, S.M.; Heng, P.W.S.; Chan, L.W. Development of Re-Usable Yeast-Gellan Gum Micro-Bioreactors for Potential Application in Continuous Fermentation to Produce Bio-Ethanol. Pharmaceutics 2011, 3, 731-744.

AMA Style

Tan SM, Heng PWS, Chan LW. Development of Re-Usable Yeast-Gellan Gum Micro-Bioreactors for Potential Application in Continuous Fermentation to Produce Bio-Ethanol. Pharmaceutics. 2011; 3(4):731-744.

Chicago/Turabian Style

Tan, Sook Mun; Heng, Paul Wan Sia; Chan, Lai Wah. 2011. "Development of Re-Usable Yeast-Gellan Gum Micro-Bioreactors for Potential Application in Continuous Fermentation to Produce Bio-Ethanol." Pharmaceutics 3, no. 4: 731-744.

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