Special Issue "Ring-Closing Metathesis"

Guest Editor
Prof. Dr. Javier Pérez-Castells
Chemistry Department, Faculty of Pharmacy, Universidad San Pablo, CEU, 28,668 Madrid, Spain
E-Mail:
Interests: organometallic chemistry; pharmaceutical chemistry; asymetric organic synthesis

Dear Colleagues,

The synthetic applications based on metathesis processes have recieved a huge attention over the past years. It has been an exciting adventure that will continue in the future based on the improvement in catalyst activity, tolerance and selectivity. New commercial and academic applications can be envisioned and the number of total synthesis of natural products based on these methodologies increases more and more. Ring closing metathesis (RCM) is an atom-economical reaction, compatible with many functional groups and allows the constuction of rings of practically any size including macrocycles. This special issue of Molecules will include new exciting contributions in RCM chemistry.

Prof. Dr. Javier Pérez-Castells
Guest Editor

Submission

• ring-closing alkene metathesis
• ring-closing alkyne metathesis
• enyne metathesis
• carbenes
• catalysis
• molybdenum
• ruthenium
• synthetic methods
• cycloisomerization

Type of Paper: Review
Title: Construction of eight-membered carbocycles with trisubstituted double bonds using the ring closing metathesis reaction
Authors: Motoo Tori and Reiko Mizutani
Affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Abstract: Medium sized carbocycles are difficult to synthesize. Recently ring closing metathesis reactions (RCM) have been applied to construction of eight-membered carbocycles. However, trisubstituted double bonds in the eight-membered rings are more difficult and tricky to realize by use of RCM reactions. In this review precedent examples and our own results are cited and discuss the importance of preparation of the suitably designed precursors. Examples of RCM reactions used in the total synthesis of natural products are also outlined.

Type of Paper: Article
Title: Mild and efficient cyclization of pent-4-en-1-ol
Authors: Marina D. Rvović and Zorica M. Bugarčić
Affiliation: University of Kragujevac, Faculty of Science, Department of Chemistry, Radoja Domanovića 12, P.O.Box 60, YU-34 000, Kragujevac, Serbia; E-Mail: zoricab@kg.ac.rs
Abstract: An innovative route for intramolecular cyclization of pent-4-en-1-ol has been delineated through a ring closing reaction with phenylselenyl halides, in good yield. Proper choice of some catalyst (triethylamine, quinoline, 2,2’-bipyridine, pyridine, CoCl₂ and SnCl₂) enables fast and facile cyclization. The reactions were performed under very mild experimental conditions, and obtained yields were almost quantitative. The reactions with catalysts present were faster then without one.
Keywords: alcohol; cyclization; catalyst; medium-ring compounds