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Special Issue "Ring-Closing Metathesis"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: closed (31 May 2010)

Special Issue Editor

Special Issue Information

Keywords

Published Papers (4 papers)

Motoo Tori and Reiko Mizutani Review: Construction of Eight-Membered Carbocycles with Trisubstituted Double Bonds Using the Ring Closing Metathesis Reaction Molecules 2010, 15(6), 4242-4260; doi:10.3390/molecules15064242 Received: 21 May 2010; in revised form: 7 June 2010 / Accepted: 10 June 2010 / Published: 11 June 2010 Show/Hide Abstract | Download PDF Full-text (1081 KB) Abstract: Medium sized carbocycles are particularly difficult to synthesize. Ring closing metathesis reactions (RCM) have recently been applied to construct eight-membered carbocycles, but trisubstituted double bonds in the eight-membered rings are more difficult to produce using RCM reactions. In this review, model examples and our own results are cited and the importance of the preparation of suitably designed precursors is discussed. Examples of RCM reactions used in the total synthesis of natural products are also outlined.

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Chen Zhang, Jian-Feng Qi, Dong-Mei Cui, Qian Wang and Xiu-Li Wang Article: Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones Molecules 2010, 15(7), 5045-5052; doi:10.3390/molecules15075045 Received: 4 June 2010; in revised form: 24 June 2010 / Accepted: 5 July 2010 / Published: 23 July 2010 Show/Hide Abstract | Download PDF Full-text (183 KB) Abstract: We have developed a Pt(COD)Cl2-catalyzed hydrative cyclization of 1,6-diynes leading to the formation of functionalized cyclohexenones in good yields.

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Guadalupe Borja, Roser Pleixats, Ramón Alibés, Xavier Cattoën and Michel Wong Chi Man Article: Organic-Inorganic Hybrid Silica Material Derived from a Monosilylated Grubbs-Hoveyda Ruthenium Carbene as a Recyclable Metathesis Catalyst Molecules 2010, 15(8), 5756-5767; doi:10.3390/molecules15085756 Received: 28 June 2010; in revised form: 10 August 2010 / Accepted: 18 August 2010 / Published: 23 August 2010 Show/Hide Abstract | Download PDF Full-text (289 KB) Abstract: The synthesis of a monosilylated Grubbs-Hoveyda ruthenium alkylidene complex is described, as well as the preparation and characterization of the corresponding material by sol-gel cogelification with tetraethoxysilane (TEOS) and the assay of this recyclable supported catalyst in ring-closing diene and enyne metathesis reactions under thermal and microwave conditions.

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Øyvind Jacobsen, Jo Klaveness and Pål Rongved Review: Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides Molecules 2010, 15(9), 6638-6677; doi:10.3390/molecules15096638 Received: 2 June 2010; in revised form: 13 September 2010 / Accepted: 15 September 2010 / Published: 21 September 2010 Show/Hide Abstract | Download PDF Full-text (892 KB) Abstract: Applications of ring-closing alkene metathesis (RCM) in acyclic α- and β-peptides and closely related systems are reviewed, with a special emphasis on the structural and pharmacological effects of cyclization by RCM.

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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Last update: 15 October 2010