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Molecules 2010, 15(9), 6638-6677; doi:10.3390/molecules15096638
Review

Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides

* ,
 and
School of Pharmacy, University of Oslo, Sem Sælands vei 3, P. O. Box 1068 Blindern, 0316 Oslo, Norway
* Author to whom correspondence should be addressed.
Received: 2 June 2010 / Revised: 13 September 2010 / Accepted: 15 September 2010 / Published: 21 September 2010
(This article belongs to the Special Issue Ring-Closing Metathesis)
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Abstract

Applications of ring-closing alkene metathesis (RCM) in acyclic α- and β-peptides and closely related systems are reviewed, with a special emphasis on the structural and pharmacological effects of cyclization by RCM.
Keywords: ring-closing metathesis; peptides; structure; pharmacological properties ring-closing metathesis; peptides; structure; pharmacological properties
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Jacobsen, Ø.; Klaveness, J.; Rongved, P. Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides. Molecules 2010, 15, 6638-6677.

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