Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides

doi:10.3390/molecules15096638

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Molecules 2010, 15(9), 6638-6677; doi:10.3390/molecules15096638

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Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides

Øyvind Jacobsen* , Jo Klaveness and Pål Rongved

School of Pharmacy, University of Oslo, Sem Sælands vei 3, P. O. Box 1068 Blindern, 0316 Oslo, Norway

* Author to whom correspondence should be addressed.

Received: 2 June 2010; in revised form: 13 September 2010 / Accepted: 15 September 2010 / Published: 21 September 2010

(This article belongs to the Special Issue Ring-Closing Metathesis)

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Abstract: Applications of ring-closing alkene metathesis (RCM) in acyclic α- and β-peptides and closely related systems are reviewed, with a special emphasis on the structural and pharmacological effects of cyclization by RCM.

Keywords: ring-closing metathesis; peptides; structure; pharmacological properties

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Cite This Article

MDPI and ACS Style

Jacobsen, Ø.; Klaveness, J.; Rongved, P. Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides. Molecules 2010, 15, 6638-6677.

AMA Style

Jacobsen Ø, Klaveness J, Rongved P. Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides. Molecules. 2010; 15(9):6638-6677.

Chicago/Turabian Style

Jacobsen, Øyvind; Klaveness, Jo; Rongved, Pål. 2010. "Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides." Molecules 15, no. 9: 6638-6677.

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